EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study
In: PLoS ONE, Jg. 8 (2013-06-24), Heft 6, p e66317, S. e66317
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Background Electronic cigarettes (e-cigarettes) are becoming increasingly popular with smokers worldwide. Users report buying them to help quit smoking, to reduce cigarette consumption, to relieve tobacco withdrawal symptoms, and to continue having a ‘smoking’ experience, but with reduced health risks. Research on e-cigarettes is urgently needed in order to ensure that the decisions of regulators, healthcare providers and consumers are based on science. Methods ECLAT is a prospective 12-month randomized, controlled trial that evaluates smoking reduction/abstinence in 300 smokers not intending to quit experimenting two different nicotine strengths of a popular e-cigarette model (‘Categoria’; Arbi Group Srl, Italy) compared to its non-nicotine choice. GroupA (n = 100) received 7.2 mg nicotine cartridges for 12 weeks; GroupB (n = 100), a 6-week 7.2 mg nicotine cartridges followed by a further 6-week 5.4 mg nicotine cartridges; GroupC (n = 100) received no-nicotine cartridges for 12 weeks. The study consisted of nine visits during which cig/day use and exhaled carbon monoxide (eCO) levels were measured. Smoking reduction and abstinence rates were calculated. Adverse events and product preferences were also reviewed. Results Declines in cig/day use and eCO levels were observed at each study visits in all three study groups (p
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EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study
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Autor/in / Beteiligte Person: | Caponnetto, Pasquale ; Caruso, Massimo ; Campagna, Davide ; Cibella, Fabio ; Morjaria, Jaymin B. ; Polosa, Riccardo ; Russo, Cristina |
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Zeitschrift: | PLoS ONE, Jg. 8 (2013-06-24), Heft 6, p e66317, S. e66317 |
Veröffentlichung: | Public Library of Science (PLoS), 2013 |
Medientyp: | unknown |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0066317 |
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