A single nucleotide polymorphism at chromosome 2q21.3 (LCT −13910C>T) associates with clinical outcome after allogeneic hematopoietic stem cell transplantation
In: Blood, Jg. 112 (2008-09-01), S. 2156-2159
Online
unknown
Zugriff:
A single nucleotide polymorphism (SNP) responsible for lactase persistence (LCT −13910C>T) changes intestinal microflora. Considering the influence of bacterial microflora on various immune effects, we tested DNA from 111 recipients/donors and analyzed whether this SNP interferes with survival and the incidence of acute graft-versus-host disease (aGVHD) after allogeneic hematopoetic stem cell tranplantations (HSCT). Median overall survival (OS) was significantly longer when donors had a CC genotype (not reached after 133 vs 11.1 months, P = .004). Multivariate analysis identified a donor T allele (hazard ratio 2.63, 95% confidence interval 1.29-5.33, P = .008) as independent risk factor for death. Surprisingly, recipient genotypes did not influence outcome and there were no differences regarding aGVHD. Transplantation-related mortality (TRM), relapse and pneumonia were significantly less frequent in patients with CC donors. These findings add to the growing list of non-HLA polymorphisms with impact on outcome after allogeneic HSCT.
Titel: |
A single nucleotide polymorphism at chromosome 2q21.3 (LCT −13910C>T) associates with clinical outcome after allogeneic hematopoietic stem cell transplantation
|
---|---|
Autor/in / Beteiligte Person: | Girschikofsky, Michael ; Krieger, Otto ; Hauser, Hanns ; Kasparu, Hedwig ; Zach, Otto ; Oberbauer, Rainer ; Lutz, Dieter ; Koenig, Josef |
Link: | |
Zeitschrift: | Blood, Jg. 112 (2008-09-01), S. 2156-2159 |
Veröffentlichung: | American Society of Hematology, 2008 |
Medientyp: | unknown |
ISSN: | 1528-0020 (print) ; 0006-4971 (print) |
DOI: | 10.1182/blood-2008-02-139766 |
Schlagwort: |
|
Sonstiges: |
|