Gorlin–Goltz syndrome and epilepsy: A two-case report and review of the literature

Gorlin–Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, is a genetic disorder with several neurological, cutaneous and skeletal manifestations. Epilepsy has been previously reported as a finding in Gorlin–Goltz syndrome but remains ill-described in the context of this disease. We report two new patients with Gorlin–Goltz syndrome featuring epilepsy and review the existing literature on the topic.

Highlights • Patients with Gorlin-Goltz syndrome may sometimes feature cognitive impairment and epilepsy. • With an onset in childhood or adulthood, seizures are generally focal to bilateral tonic-clonic. • Epileptiform activity may either involve the frontal, temporal or parietal lobe. • Epilepsy surgery, such as lesionectomy or lobectomy, can be a treatment option in well selected drug-resistant patients. • The Sonic Hedgehog pathway may be involved in the pathophysiology of seizures in this syndrome.