A xylanase from roots of sanchi ginseng (Panax notoginseng) with inhibitory effects on human immunodeficiency virus-1 reverse transcriptase
In: Life sciences, Jg. 70 (2002-07-26), Heft 25
Online
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Zugriff:
A xylanase with a molecular weight of 15 kDa, which is lower than those of previously reported xylanases, was isolated from the roots of the medicinal herb Panax notoginseng. The xylanase exhibits a temperature optimum of 50 degrees C and a pH optimum between 5 and 6. It inhibits HIV-1 reverse transcriptase with an IC(50) of 10 microM, but does not affect translation in a cell-free rabbit reticulocyte system when tested up to 70 microM. The enzyme is adsorbed on CM-cellulose, Affi-gel blue gel and Mono S. Previously xylanases have been isolated from seeds and not from roots, and have not been demonstrated to inhibit HIV-1 reverse transcriptase.
Titel: |
A xylanase from roots of sanchi ginseng (Panax notoginseng) with inhibitory effects on human immunodeficiency virus-1 reverse transcriptase
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Autor/in / Beteiligte Person: | Tzi Bun Ng ; Lam, Sze-Kwan |
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Zeitschrift: | Life sciences, Jg. 70 (2002-07-26), Heft 25 |
Veröffentlichung: | 2002 |
Medientyp: | unknown |
ISSN: | 0024-3205 (print) |
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