Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo
In: Journal of molecular and cellular cardiology, Jg. 39 (2004-12-17), Heft 2
Online
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Zugriff:
Over activation of the renin-angiotensin-aldosterone system is known to be cardiotoxic but the potential injurious effects on the skeletal musculature have not been investigated. Male Wistar rats were given subcutaneous injections of aldosterone (1 microg-10 mg kg-1) and killed 7 h later, or continuous infusion (1 mg kg-1 d-1) and killed 48 h later. The role of the mineralocorticoid receptor in mediating aldosterone-induced apoptosis in vivo was investigated using spironolactone (200 mg kg-1). The number of apoptotic (caspase 3 positive) myocytes was counted on cryosections of the heart, soleus and Tibialis Anterior muscles. Injections of aldosterone induced significant (P
Titel: |
Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo
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Autor/in / Beteiligte Person: | Burniston, Jatin G. ; Saini, Amarjit ; Goldspink, David F. ; Tan, Lip-Bun |
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Zeitschrift: | Journal of molecular and cellular cardiology, Jg. 39 (2004-12-17), Heft 2 |
Veröffentlichung: | 2004 |
Medientyp: | unknown |
ISSN: | 0022-2828 (print) |
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