Cytomegalovirus specific polyfunctional T-cell responses expressing CD107a predict control of CMV infection after liver transplantation
In: Cellular immunology, Jg. 371 (2021-07-23)
Online
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Zugriff:
Cytomegalovirus (CMV) viral load after liver transplantation (LT) is controlled by cell mediated immune responses (CMI). Quantification of CMV-specific T-cells may identify patients who control CMV spontaneously and avoid expensive and potentially toxic antiviral therapies. Prospective post-LT clinical, virological and immunological monitoring was carried out up to 1-year post-LT in a cohort of adult recipients. The CMV-specific T-cell response was characterized using flow cytometry intracellular cytokine staining in 49 LT recipients-R (79.6% R+, 20.4% R-). CMV infection occurred in 24 patients (18 D+/R+ and 6 D+/R-). Only patients with undetectable polyfunctional CMV-specific CD4+ T-cells developed CMV infection. Predictive models showed that polyfunctional CMV-specific CD4+ T-cells pre-existing before LT are protective for CMV reactivation posttransplantation. Quantitation of CD4+ T-cell responses to CMV may be a useful marker for spontaneous control of viral replication to tailor antiviral prophylaxis after LT.
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Cytomegalovirus specific polyfunctional T-cell responses expressing CD107a predict control of CMV infection after liver transplantation
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Autor/in / Beteiligte Person: | Pallarés, Carmina ; Aguilera, Victoria ; Berenguer, Marina ; Cubells, Almudena ; Carvalho-Gomes, Ângela ; F. Xavier López-Labrador ; Corpas-Burgos, Francisca |
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Zeitschrift: | Cellular immunology, Jg. 371 (2021-07-23) |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 1090-2163 (print) ; 0008-8749 (print) |
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