Clinical and economic impact of treated CMV infection in adult CMV‐seropositive patients after allogeneic hematopoietic cell transplantation
In: Journal of Medical Virology Journal of Medical Virology, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩ Journal of Medical Virology, Wiley-Blackwell, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩; (2020-12-01)
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OBJECTIVE Recipients of allogeneic hematopoietic stem cell transplantation (allo-HCT) with positive cytomegalovirus (CMV) serology are at increased risk of morbidity and mortality. The primary objective of this study was to assess the association between treated CMV infection and overall mortality within 1 year after allo-HCT in adult CMV-seropositive Recipients (R+). Secondary objectives included overall 5-year mortality after allo-HCT, risk factors for treated CMV infection, associations between treated CMV infection and allo-HCT complications and medical costs. METHODS A multicenter retrospective cohort study was conducted in adult CMV-seropositive recipients (R+) who underwent to allo-HCT between 1st January 2010 and 31st December 2014. RESULTS Five hundred seventy two CMV-seropositive patients (mean age, 50.2 years) undergoing allo-HCT between 2010 and 2014 were included; 55.9% of donors were CMV seropositive. CMV infection treated with antiviral therapy was reported in 227 patients (39.7%) after transplantation. One-year overall mortality was significantly increased in patients with treated CMV infections (hazard ratio, 1.86; 95% CI, 1.16-3.00; P = .011). Mean medical costs during the first post-HCT year were higher in patients with CMV infection (€46 853 vs €31 318; P
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Clinical and economic impact of treated CMV infection in adult CMV‐seropositive patients after allogeneic hematopoietic cell transplantation
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Autor/in / Beteiligte Person: | Blomkvist, Josefin ; Yakoub-Agha, Ibrahim ; Levy‐Bachelot, Laurie ; Chevallier, Patrice ; Blaise, Didier ; Srour, Micha ; Allavoine, Thierry ; Alami, Sarah ; Tadmouri, Abir ; Régis Peffault de Latour ; Beauvais, David ; Duhamel, Alain ; Centre de Recherche en Cancérologie de Marseille (CRCM) ; Aix Marseille Université (AMU)-Institut Paoli-Calmettes ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU) |
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Quelle: | Journal of Medical Virology Journal of Medical Virology, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩ Journal of Medical Virology, Wiley-Blackwell, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩; (2020-12-01) |
Veröffentlichung: | HAL CCSD, 2020 |
Medientyp: | unknown |
ISSN: | 0146-6615 (print) ; 1096-9071 (print) |
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