Toxicity associated with combination chemotherapy for osteosarcoma: A report of the cooperative osteosarcoma study (COSS 80)
In: Journal of Cancer Research and Clinical Oncology, Jg. 106 (1983), S. 14-18
Online
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Zugriff:
The treatment-associated toxicity in 189 patients entered in the COSS-80 Study was analyzed. The sequential use of high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR) and cis-platinum may be additive or synergistic in causing renal toxicity. However, evaluation of the 48-h serum methotrexate level and the incidence of elevated serum creatinine levels throughout treatment failed to indicate prolonged methotrexate elimination or severe kidney damage from this regimen where an interval of 3 weeks between cis-platinum administration and the next course of HDMTX was mandatory. The treatment-related mortality was 3.2% (6 out of 189 patients). Three patients died of septicemia during chemotherapy-induced bone-marrow depression following treatment with adriamycin or the combination of bleomycin, cyclophosphamide, and dactinomycin (BCD). Three deaths occurred following the use of high-dose methotrexate with citrovorum factor rescue. Two of these deaths were associated with delayed excretion of methotrexate. The toxicity is within the range reported in the literature.
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Toxicity associated with combination chemotherapy for osteosarcoma: A report of the cooperative osteosarcoma study (COSS 80)
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Autor/in / Beteiligte Person: | Jürgens, H. ; Winkler, K. ; Beron, G. |
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Zeitschrift: | Journal of Cancer Research and Clinical Oncology, Jg. 106 (1983), S. 14-18 |
Veröffentlichung: | Springer Science and Business Media LLC, 1983 |
Medientyp: | unknown |
ISSN: | 1432-1335 (print) ; 0171-5216 (print) |
DOI: | 10.1007/bf00625045 |
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