Targeted assessment of lower motor neuron burden is associated with survival in amyotrophic lateral sclerosis
In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Jg. 17 (2015-12-24), S. 184-190
Online
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Zugriff:
Estimating survival in amyotrophic lateral sclerosis (ALS) is challenging due to heterogeneity in clinical features of disease and a lack of suitable markers that predict survival. Our aim was to determine whether scoring of upper or lower motor neuron weakness is associated with survival. With this objective, 161 ALS subjects were recruited from two tertiary referral centres. Scoring of upper (UMN) and lower motor neuron (LMN) signs was performed, in addition to a brief questionnaire. Subjects were then followed until the censorship date. Univariate analysis was performed to identify variables associated with survival to either non-invasive ventilation (NIV) or death, which were then further characterized using Cox regression. Results showed that factors associated with reduced survival included older age, bulbar and respiratory involvement and shorter diagnostic delay (all p
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Targeted assessment of lower motor neuron burden is associated with survival in amyotrophic lateral sclerosis
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Autor/in / Beteiligte Person: | McCombe, Pamela A. ; Ballard, Emma ; Kiernan, Matthew C. ; Matthew S Devine ; Henderson, Robert D. ; O'Rourke, Peter |
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Zeitschrift: | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Jg. 17 (2015-12-24), S. 184-190 |
Veröffentlichung: | Informa UK Limited, 2015 |
Medientyp: | unknown |
ISSN: | 2167-9223 (print) ; 2167-8421 (print) |
DOI: | 10.3109/21678421.2015.1125502 |
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