Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?
In: Oncogene, Jg. 21 (2002-01-21), S. 688-697
Online
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Zugriff:
Telomerase activation is observed in almost 90% of human cancers but not in normal tissues of somatic origin and thus is a critical step for multistep carcinogenesis. A more thorough understanding of telomerase regulation may provide not only a molecular basis of cancer progression but also as a way to manipulate telomerase activity as a potential therapeutic modality. Recent progress in studies on telomerase regulation has shown that telomerase activation is achieved at various steps, including transcriptional and post-transcriptional levels of the telomerase reverse transcriptase (hTERT) gene. Although a number of potentially important mechanisms of telomerase activation have been proposed, none of the current models can fully explain tumor-specific activation of telomerase, suggesting a need for further extensive analysis. This review includes a summary of recent works on telomerase regulation and a discussion of how we can overcome this situation.
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Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?
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Autor/in / Beteiligte Person: | Inoue, Masaki ; Kyo, Satoru |
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Zeitschrift: | Oncogene, Jg. 21 (2002-01-21), S. 688-697 |
Veröffentlichung: | Springer Science and Business Media LLC, 2002 |
Medientyp: | unknown |
ISSN: | 1476-5594 (print) ; 0950-9232 (print) |
DOI: | 10.1038/sj.onc.1205163 |
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