Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients
In: Mediators of Inflammation Mediators of Inflammation, 2017, pp.7960907, 2017, ⟨10.1155/2017/7960907⟩ Mediators of Inflammation, Vol 2017 (2017); (2017)
Online
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Zugriff:
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of lymphoma, with different clinical manifestation and prognosis. The International Prognostic Index (IPI), an index designed during the prerituximab era for aggressive lymphoma, showed variable values in the prediction of patient clinical outcomes. The aim of this study was to analyze the prognostic value and causes of pretreatment liver injury in 363 de novo DLBCL patients in our institution. Pretreatment liver impairment, commonly detected in lymphoma patients, showed significant association with poor outcomes and increased serum inflammatory cytokines in DLBCL patients but had no relation to hepatitis B virus replication nor lymphomatous hepatic infiltration. Multivariate analysis revealed that liver dysfunction, advanced Ann Arbor stage, and elevated lactate dehydrogenase (LDH) were independent adverse prognostic factors of both PFS and OS. Accordingly, a new liver-IPI prognostic model was designed by adding liver injury as an important factor in determining IPI score. Based on Kaplan-Meier curves for PFS and OS, the liver-IPI showed better stratification in DLBCL patients than either the IPI or the revised IPI in survival prediction.
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Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients
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| Autor/in / Beteiligte Person: | Leboeuf, Christophe ; Shi, Qing ; Shen, Rong ; Ou-Yang, Bin-Shen ; Wang, Li ; Cheng, Shu ; Janin, Anne ; Zhao, Yan ; Fan, Xing ; Wang, Chao-Fu ; Zhao, Wei-Li ; Qian, Ying ; leboeuf, Christophe ; Shanghai Jiao Tong University School of Medicine ; Pennsylvania State University (Penn State) ; Penn State System ; Laboratoire de pathologie, Hôpital Saint-Louis ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Biomedical Research Imaging Center [North Carolina] (BRIC) ; University of North Carolina [Chapel Hill] (UNC) ; University of North Carolina System (UNC)-University of North Carolina System (UNC) ; Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord ; Laboratoire de pathologie [AP-HP Hôpital Saint-Louis] ; Hopital Saint-Louis [AP-HP] (AP-HP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Cancer et Transplantation : Physiopathologie et Réponse Thérapeutique (UMR 1165) ; Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
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| Quelle: | Mediators of Inflammation Mediators of Inflammation, 2017, pp.7960907, 2017, ⟨10.1155/2017/7960907⟩ Mediators of Inflammation, Vol 2017 (2017); (2017) |
| Veröffentlichung: | HAL CCSD, 2017 |
| Medientyp: | unknown |
| ISSN: | 0962-9351 (print) ; 1466-1861 (print) |
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