Is acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF
In: European Journal of Heart Failure r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname EUROPEAN JOURNAL OF HEART FAILURE r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA European Journal of Heart Failure, 23(1), 43-57. Wiley European Journal of Heart Failure, 2021, 23 (1), pp.43-57. ⟨10.1002/ejhf.2077⟩; (2021)
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Zugriff:
Aims: \ud This retrospective analysis sought to identify markers that might distinguish between acute heart failure (HF) and worsening HF in chronic outpatients.\ud \ud Methods and Results: \ud The BIOSTAT‐CHF index cohort included 2516 patients with new or worsening HF symptoms: 1694 enrolled as inpatients (acute HF) and 822 as outpatients (worsening HF in chronic outpatients). A validation cohort included 935 inpatients and 803 outpatients. Multivariable models were developed in the index cohort using clinical characteristics, routine laboratory values, and proteomics data to examine which factors predict adverse outcomes in both conditions and to determine which factors differ between acute HF and worsening HF in chronic outpatients, validated in the validation cohort.\ud \ud Patients with acute HF had substantially higher morbidity and mortality (6 months mortality was 12..3% for acute HF and 4..7% for worsening HF in chronic outpatients). Multivariable models predicting 180‐day mortality and 180‐day HF re‐admission differed substantially between acute HF and worsening HF in chronic outpatients. CA‐125 was the strongest single biomarker to distinguish acute HF from worsening HF in chronic outpatients, but only yielded a C‐index of 0..71. A model including multiple biomarkers and clinical variables achieved a high degree of discrimination with a C‐index of 0..913 in the index cohort and 0..901 in the validation cohort.\ud \ud Conclusion: \ud The study identifies different characteristics and predictors of outcome in acute HF patients as compared to outpatients with chronic HF developing worsening HF. The markers identified may be useful in better diagnosing acute HF and may become targets for treatment development.
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Is acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF
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Autor/in / Beteiligte Person: | Koch, Gary G. ; Núñez, Julio ; Ng, Leong L. ; Filippatos, Gerasimos ; Mebazaa, Alexandre ; Senger, Stefanie ; Mordi, Ify R. ; Peter van der Meer ; Metra, Marco ; Lang, Chim C. ; Hillege, Hans L. ; Ponikowski, Piotr ; John G.F. Cleland ; Anker, Stefan D. ; Dirk J. van Veldhuisen ; Voors, Adriaan A. ; Cotter, Gad ; Edwards, Christopher L. ; Davison, Beth A. ; Iziah E Sama ; Samani, Nilesh J. ; Dickstein, Kenneth ; Zannad, Faiez ; Bayes-Genis, Antoni ; Groningen Kidney Center (GKC) ; Life Course Epidemiology (LCE) ; Cardiovascular Centre (CVC) ; Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) ; Momentum Research Inc., Durham ; Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord ; University Medical Center Groningen [Groningen] (UMCG) ; University of North Carolina [Chapel Hill] (UNC) ; University of North Carolina System (UNC) ; Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal ; University of Bergen (UiB) ; Stavanger University Hospital ; NIHR Leicester Biomedical Research Centre, Glenfield Hospital ; Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia] ; Charité Campus Virchow-Klinikum (CVK) ; Berlin-Brandenburg Center for Regenerative Therapies [Berlin, Germany] ; Charité - UniversitätsMedizin = Charité - University Hospital [Berlin] ; Berlin Institute of Health Center for Regenerative Therapies ; German Center for Cardiovascular Research (DZHK) ; Berlin Institute of Health (BIH) ; National Heart and Lung Institute [London] (NHLI) ; Imperial College London-Royal Brompton and Harefield NHS Foundation Trust ; Imperial College London ; Ninewells Hospital and Medical School [Dundee] ; Défaillance Cardiovasculaire Aiguë et Chronique (DCAC) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL) ; Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P) ; Centre d'investigation clinique [Nancy] (CIC) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL) ; Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT) ; Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy] ; French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ) ; National and Kapodistrian University of Athens (NKUA) ; University of Groningen [Groningen] ; Wrocław Medical University ; Universitat de València (UV) ; Biomedical Research Institute [Valencia, Spain] (INCLIVA ) ; Germans Trias i Pujol University Hospital [Badalona, Barcelona, Spain] (GTPUH) ; BIOSTAT-CHF was funded by the European Commission [FP7-242209-BIOSTAT-CHF ; 2010-020808-29]., EudraCT ; European Project: 242209,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,BIOSTAT-CHF(2010) ; Project, European ; BOZEC, Erwan ; A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure - BIOSTAT-CHF - - EC:FP7:HEALTH2010-04-01 - 2015-03-31 - 242209 -, VALID ; EudraCT 2010–020808–29 -, INCOMING |
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Quelle: | European Journal of Heart Failure r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname EUROPEAN JOURNAL OF HEART FAILURE r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA European Journal of Heart Failure, 23(1), 43-57. Wiley European Journal of Heart Failure, 2021, 23 (1), pp.43-57. ⟨10.1002/ejhf.2077⟩; (2021) |
Veröffentlichung: | Wiley-Blackwell, 2021 |
Medientyp: | unknown |
ISSN: | 1388-9842 (print) ; 1879-0844 (print) |
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