Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus
In: Lupus, Jg. 30 (2021-01-26), S. 734-740
Online
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Zugriff:
Background: Abnormal expression and function of long non-coding RNAs (lncRNAs) are closely related to the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the association of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) gene single-nucleotide polymorphisms (SNPs) with susceptibility and clinical characteristics of SLE patients. Methods: A case-control study including 489 SLE patients and 492 healthy controls was conducted. Four MALAT-1 SNPs (rs4102217, rs591291, rs11227209, and rs619586) were genotyped in all subjects, their correlation with SLE susceptibility and clinical characteristics were also analyzed. Results: Results showed that the rs4102217 locus was associated with the risk of SLE. In recessive models, the GG+CG genotype of rs4102217 was associated with the decreased risk of SLE compared to CC (p = 0.036, OR = 0.348, 95% CI: 0.124-0.975). In additive models, the GG genotype of rs4102217 was associated with the decreased risk of SLE compared to CC (p = 0.040, OR = 0.355, 95% CI: 0.127-0.996). However, no association was found between MALAT-1 gene polymorphism and clinical manifestations of SLE (all p > 0.05). Conclusion: In summary, MALAT-1 rs4102217 is associated with susceptibility to SLE, suggesting that MALAT-1 may play a role in SLE.
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Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus
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Autor/in / Beteiligte Person: | Dan, Yi-Lin ; Zhao, Chan-Na ; Wu, Guo-Cui ; Mao, Yan-Mei ; Xiang, Kun ; Pan, Hai-Feng ; Yang, Xiao-Ke ; Wu, Qian ; He, Yi-Sheng ; Napoleon Bellua Sam ; Hu, Yu-Qian |
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Zeitschrift: | Lupus, Jg. 30 (2021-01-26), S. 734-740 |
Veröffentlichung: | SAGE Publications, 2021 |
Medientyp: | unknown |
ISSN: | 1477-0962 (print) ; 0961-2033 (print) |
DOI: | 10.1177/0961203321989794 |
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