Plasma lipid peroxidation and progression of disability in multiple sclerosis
In: European journal of neurology, Jg. 14 (2007-04-18), Heft 5
Online
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Zugriff:
Oxidative stress has been implicated in the pathophysiology of multiple sclerosis (MS), but its relation to disease progression is uncertain. To evaluate the relationship of plasma lipid peroxidation with progression of disability in MS, we measured blood plasma fluorescent lipid peroxidation products (PFLPP) levels in 23 patients with RRMS with a benign course, 32 with secondary progressive MS, 24 with primary progressive MS and 30 healthy controls. None of the patients had a relapse within the previous 3 months. Progression of disability was evaluated during a follow-up period of 5 years by the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Severity Score (MSSS). We found plasma PFLPP levels elevated in patients with MS compared with controls (P
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Plasma lipid peroxidation and progression of disability in multiple sclerosis
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Autor/in / Beteiligte Person: | Koch, Marcus W. ; Heersema, Dorothea ; Teelken, A ; de Jacques Keyser ; Arutjunyan, AV ; Mostert, Jop P. ; Stepanov, M. ; Gerontology |
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Zeitschrift: | European journal of neurology, Jg. 14 (2007-04-18), Heft 5 |
Veröffentlichung: | 2007 |
Medientyp: | unknown |
ISSN: | 1468-1331 (print) ; 1351-5101 (print) |
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