Reactive astrocyte nomenclature, definitions, and future directions
In: Nature neuroscience 24(3), 312-325 (2021). doi:10.1038/s41593-020-00783-4 Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, G C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K K, Norris, C M, Okada, S, Oliet, S H R, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanzer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J D, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience, vol. 24, pp. 312–325 https://doi.org/10.1038/s41593-020-00783-4 Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩ Nat Neurosci Nature Neuroscience, Nature Publishing Group, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩ Nature neuroscience, vol 24, iss 3 Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩ Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, C C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K, Norris, C M, Okada, S, Oliet, S HR, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanazer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience . https://doi.org/10.1038/s41593-020-00783-4
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Zugriff:
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters—preferably in vivo—plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.
Funding: CNRS, CEA, ANR, and France Alzheimer to CE.; MCINN (PID2019-107633RB-I00) and Generalitat de Catalunya (2017-SGR547, Grup de demències Sant Pau) to E.G. US Centers for Disease Control and Prevention to J. P.O. Alzheimer’s Association (AACF-17-524184) and NIH-NIA (K08AG064039) to A.S.-P. DFG (SPP1757, STE 552/5, STE 552/4), EU (H2020-MSCA-ITN project 722053 EU-GliaPhD) and BMBF (16GW0182 CONNEXIN) to C.S. Swiss National Science Foundation grant 31003A 173124/1; SNSF NCCR ‘Transcure’ (51NF40-160620); Synapsis Foundation Heidi Seiler-Stiftung 2018-PI01 to A.Volterra. NIH-NINDS (NS084030), Dr. Miriam and Sheldon G. Adelson Medical Foundation and Wings for Life to M.V.S. The authors thank T. Yohannan of Alpha Language Services, Barcelona, for expert copy editing.
| Titel: |
Reactive astrocyte nomenclature, definitions, and future directions
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| Autor/in / Beteiligte Person: | Butt, Arthur M. ; Galea, Elena ; Ransohoff, Richard M. ; Swanson, Raymond A. ; Zimmer, Eduardo R. ; Norris, Christopher M. ; Bonvento, Gilles ; Lakatos, Andras ; Haydon, Philip G. ; Wei Ting Chen ; Rose, Christine R. ; Semyanov, Alexey ; Allen, Nicola J. ; Molofsky, Anna V. ; Vitorica, Javier ; Okada, Seiji ; Araque, Alfonso ; Gutierrez, Antonia ; Iino, Masamitsu ; Serrano-Pozo, Alberto ; Gallo, Vittorio ; C. Justin Lee ; Götz, Magdalena ; Khakh, Baljit S. ; Steinhäuser, Christian ; Bart De Strooper ; Oliet, Stéphane H. R. ; Volterra, Andrea ; Sirko, Swetlana ; Poskanzer, Kira E. ; Sofroniew, Michael V. ; Carmignoto, Giorgio ; Hol, Elly M. ; Pfrieger, Frank W. ; Pérez-Nievas, Beatriz G. ; Kastanenka, Ksenia V. ; Murai, Keith K. ; O'Callaghan, James P. ; Wanner, Ina B. ; Rowitch, David H. ; Magistretti, Pierre J. ; Farina, Cinthia ; Pekna, Marcela ; Messing, Albee ; Jia Qian Wu ; Liddelow, Shane A. ; Dieter Henrik Heiland ; Mishra, Anusha ; Zorec, Robert ; Wood, Levi B. ; Freeman, Marc R. ; Holt, Matthew ; Barbeito, Luis ; Petzold, Gabor C. ; Pellerin, Luc ; Rothstein, Jeffrey D. ; Rouach, Nathalie ; Escartin, Carole ; Koizumi, Schuichi ; Perea, Gertrudis ; Bergles, Dwight E. ; Riquelme-Perez, Miriam ; Cohen-Salmon, Martine ; Robel, Stefanie ; Goldman, James E. ; Zheng, Binhai ; João Filipe Oliveira ; Barzilai, Ari ; Goldman, Steven A. ; MacVicar, Brian A. ; Panatier, Aude ; Kettenmann, Helmut ; Verkhratsky, Alexei ; Agarwal, Amit ; Cunningham, Colm ; Diaz-Castro, Blanca ; Quintana, Francisco J. ; Pekny, Milos ; Sontheimer, Harald ; Deneen, Benjamin ; Parpura, Vladimir ; Service MIRCEN (MIRCEN) ; Institut de Biologie François JACOB (JACOB) ; Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay ; Universitat Autònoma de Barcelona (UAB) ; ICREA Infection Biology Laboratory (Department of Experimental and Health Sciences) ; Universitat Pompeu Fabra [Barcelona] (UPF) ; University of Cambridge [UK] (CAM) ; National Institute for Occupational Safety and Health [Morgantown, WV, USA] (NIOSH) ; German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) ; University Hospital Bonn ; Massachusetts General Hospital [Charlestown, MA, États-Unis] ; University of Bonn ; University of Lausanne (UNIL) ; Italian National Research Council [Padova, Italy] ; University of Padua [Italy] ; University, Heidelberg ; The Salk Institute for Biological Studies ; University of Minnesota [MN, USA] ; Institut Pasteur de Montevideo ; Réseau International des Instituts Pasteur (RIIP) ; Tel Aviv University [Tel Aviv] ; Johns Hopkins University School of Medicine [Baltimore] ; University of Portsmouth ; Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven) ; Centre interdisciplinaire de recherche en biologie (CIRB) ; MemoLife, Labex ; École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris) ; Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Trinity College Dublin ; Baylor College of Medicine (BCM) ; University, Baylor ; University College of London [London] (UCL) ; University of Edinburgh ; San Raffaele Scientific Institute ; Vita-Salute San Raffaele University and Center for Translational Genomics and Bioinformatics ; Institute, Vollum ; Vollum Institute, OHSU ; National Children's Hospital ; Columbia University [New York] ; University of Rochester Medical Center (URMC) ; University of Copenhagen = Københavns Universitet (KU) ; Ludwig Maximilians Universitaet ; SYNERGY, Excellence Cluster of Systems Neurology ; Ludwig-Maximilians-Universität München (LMU) ; Universidad de Málaga [Málaga] = University of Málaga [Málaga] ; Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) ; Instituto de Salud Carlos III [Madrid] (ISC) ; Tufts University School of Medicine [Boston] ; University of Freiburg [Freiburg] ; Utrecht University [Utrecht] ; VIB-KU Leuven Center for Brain & Disease Research [Leuven, Belgium] ; Nihon University School of Medicine [Tokyo, Japan] ; Max Delbrück Center for Molecular Medicine [Berlin] (MDC) ; Helmholtz-Gemeinschaft = Helmholtz Association ; David Geffen School of Medicine [Los Angeles] ; University of California [Los Angeles] (UCLA) ; University of California-University of California ; University, Yamanashi ; Institute for Basic Science [Daejeon] (IBS) ; New York University School of Medicine (NYU) ; New York University School of Medicine ; NYU System (NYU)-NYU System (NYU) ; University of British Columbia (UBC) ; King Abdullah University of Science and Technology ; University of Wisconsin-Madison ; Oregon Health and Science University [Portland] (OHSU) ; University of California [San Francisco] (UCSF) ; University of California ; McGill University Health Center [Montreal] (MUHC) ; University of Kentucky ; Kyushu University [Fukuoka] ; Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm) ; Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM) ; University of Minho [Braga] ; ICVS/3B's—PT Government Associate Laboratory [Braga, Portugal] ; Polytechnic Institute of Cávado and Ave ; University of Alabama at Birmingham [ Birmingham] (UAB) ; University of Gothenburg (GU) ; Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT) ; Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Institute, Cajal ; King‘s College London ; Institut des Neurosciences Cellulaires et Intégratives (INCI) ; Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) ; Brigham & Women’s Hospital [Boston] (BWH) ; Harvard Medical School [Boston] (HMS) ; Third Rock Ventures ; Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] ; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) ; Russian Academy of Sciences [Moscow] (RAS) ; Sechenov First Moscow State Medical University ; Ludwig Maximilian University [Munich] (LMU) ; Institute for Stem Cell Research [Neuherberg] ; Helmholtz-Zentrum München (HZM) ; Universidad de Sevilla ; Georgia Institute of Technology [Atlanta] ; The University of Texas Health Science Center at Houston (UTHealth) ; UC San Diego School of Medicine ; Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS) ; University of Ljubljana ; University of Manchester [Manchester] ; Ikerbasque - Basque Foundation for Science ; Université Paris-Saclay-Institut de Biologie François JACOB (JACOB) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; European Project: 722053,EU-GliaPhD - H2020-EU.1.3. H2020-EU.1.3.1. ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris) ; Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB) ; Universität Bonn = University of Bonn ; Université de Lausanne = University of Lausanne (UNIL) ; Escartin, Carole [0000-0003-3613-4118] ; Galea, Elena [0000-0003-4537-9897] ; Lakatos, András [0000-0002-1301-2292] ; Petzold, Gabor C [0000-0002-0145-8641] ; Serrano-Pozo, Alberto [0000-0003-0899-7530] ; Volterra, Andrea [0000-0003-1069-1602] ; Araque, Alfonso [0000-0003-3840-1144] ; Barbeito, Luis [0000-0002-3047-232X] ; Bonvento, Gilles [0000-0002-2886-4228] ; Butt, Arthur M [0000-0001-7579-0746] ; Deneen, Benjamin [0000-0002-6335-1081] ; Farina, Cinthia [0000-0002-4466-9676] ; Gallo, Vittorio [0000-0002-2429-0845] ; Goldman, Steven A [0000-0002-5498-4303] ; Götz, Magdalena [0000-0003-1551-9203] ; Gutiérrez, Antonia [0000-0002-6264-6152] ; Haydon, Philip G [0000-0001-5698-6698] ; Heiland, Dieter H [0000-0002-9258-3033] ; Hol, Elly M [0000-0001-5604-2603] ; Holt, Matthew G [0000-0002-8958-4027] ; Koizumi, Schuichi [0000-0001-6184-3106] ; MacVicar, Brian A [0000-0003-4596-4623] ; Mishra, Anusha [0000-0002-3642-5049] ; Molofsky, Anna V [0000-0002-4709-2411] ; Okada, Seiji [0000-0002-5107-8209] ; Oliveira, João F [0000-0002-1005-2328] ; Panatier, Aude [0000-0002-6107-4463] ; Pekna, Marcela [0000-0003-2734-8237] ; Perea, Gertrudis [0000-0001-5924-9175] ; Pfrieger, Frank W [0000-0001-7085-1431] ; Poskanzer, Kira E [0000-0003-4830-8891] ; Rose, Christine R [0000-0002-9684-3592] ; Rothstein, Jeffrey D [0000-0003-2001-8470] ; Rouach, Nathalie [0000-0002-5574-888X] ; Rowitch, David H [0000-0002-0079-0060] ; Semyanov, Alexey [0000-0002-6800-0942] ; Sirko, Swetlana [0000-0001-5950-616X] ; Sontheimer, Harald [0000-0002-5843-9871] ; Swanson, Raymond A [0000-0002-3664-5359] ; Zorec, Robert [0000-0002-7478-3875] ; Sofroniew, Michael V [0000-0001-6075-0178] ; Verkhratsky, Alexei [0000-0003-2592-9898] ; Apollo - University of Cambridge Repository |
| Link: | |
| Quelle: | Nature neuroscience 24(3), 312-325 (2021). doi:10.1038/s41593-020-00783-4 Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, G C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K K, Norris, C M, Okada, S, Oliet, S H R, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanzer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J D, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience, vol. 24, pp. 312–325 https://doi.org/10.1038/s41593-020-00783-4 Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩ Nat Neurosci Nature Neuroscience, Nature Publishing Group, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩ Nature neuroscience, vol 24, iss 3 Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩ Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, C C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K, Norris, C M, Okada, S, Oliet, S HR, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanazer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience . https://doi.org/10.1038/s41593-020-00783-4 |
| Veröffentlichung: | Nature America, 2021 |
| Medientyp: | unknown |
| ISSN: | 1097-6256 (print) ; 1546-1726 (print) |
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