Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav
In: FEBS letters, Jg. 472 (2000-04-27), Heft 1
Online
unknown
Zugriff:
Mammalian Vav signal transducer protein couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. We have isolated and characterized the DroVav gene, the homologue of hVav in Drosophila melanogaster. DroVav encodes a protein (793 residues) whose similarity with hVav is 47% and with hVav2 and hVav3 is 45%. DroVav preserves the unique, complex structure of hVav proteins, including the ‘calponin homology’, dbl homology, pleckstrin homology; SH2 and SH3 domains in addition to regions that are acidic rich, proline rich and cysteine rich. DroVav is located on the X chromosome in polytene interval 18A5;18B and is expressed in all stages of development and in all tissues. In mammalian cells, DroVav is tyrosine-phosphorylated in response to epidermal growth factor receptor (EGFR) induction; in vitro, the DroVav SH2 region is associated with tyrosine-phosphorylated EGFR. Thus, DroVav probably plays a pivotal role as a signal transducer protein during fruit fly development.
Titel: |
Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav
|
---|---|
Autor/in / Beteiligte Person: | Dekel, Idit ; Katzav, Shulamit ; Russek, Niva ; Jones, Tamara L. ; Mortin, Mark A. |
Link: | |
Zeitschrift: | FEBS letters, Jg. 472 (2000-04-27), Heft 1 |
Veröffentlichung: | 2000 |
Medientyp: | unknown |
ISSN: | 0014-5793 (print) |
Schlagwort: |
|
Sonstiges: |
|