Impact of 12 weeks nab-paclitaxel + carboplatin or gemcitabine followed by anthracycline administration according to pCR in triple-negative early breast cancer: Survival results of WSG-ADAPT-TN phase II trial
In: Journal of Clinical Oncology, Jg. 36 (2018-05-20), S. 573-573
Online
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Zugriff:
573Background: Optimal chemotherapy in TNBC EBC is unclear. ADAPT TN demonstrated higher pCR (46% vs. 29%) and better safety for only 12 weeks nab-paclitaxel/carboplatin vs nab-paclitaxel/gemcitabine (JNCI 2017). Methods: Patients with centrally confirmed TNBC (ER/PR < 1%, HER2-, cT1c-cT4c, cN0/+) were randomized to neoadjuvant A: 4x nab-paclitaxel 125 mg/m2/gemcitabine 1000 mg/m2 d1,8 q3w vs. B: 4x nab-paclitaxel 125 mg/m2/carboplatin AUC2 day 1/8 3-weekly (q3w). Primary endpoint was pCR (ypT0/is/ypN0) after 12 weeks of therapy. Event-free (EFS) -- defined as time from registration to any invasive relapse, secondary malignancy or death of any cause -- and overall survival (OS) were secondary endpoints. Adjuvant anthracycline-based chemotherapy (4xEC) was optional in patients with pCR. Here, we report the per-protocol interim survival analysis recommended by the DSMB after a median follow-up of 3 years. Results: 336 patients were enrolled (48 centers, arms A/B: n = 182/154). Median age was 50 years. At ba...
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Impact of 12 weeks nab-paclitaxel + carboplatin or gemcitabine followed by anthracycline administration according to pCR in triple-negative early breast cancer: Survival results of WSG-ADAPT-TN phase II trial
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Autor/in / Beteiligte Person: | Braun, Michael ; Liedtke, Cornelia ; Hackmann, John ; Uleer, Christoph ; Harbeck, Nadia ; Christgen, Matthias ; Kümmel, Sherko ; Wuerstlein, Rachel ; Warm, Mathias ; Gluz, Oleg ; Forstbauer, Helmut ; Aktas, Bahriye ; Kates, Ronald E. ; Nitz, Ulrike ; Kreipe, Hans ; Grischke, Eva-Maria ; Schumacher, Claudia ; Lindner, Christoph ; Bangemann, Nikola |
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Zeitschrift: | Journal of Clinical Oncology, Jg. 36 (2018-05-20), S. 573-573 |
Veröffentlichung: | American Society of Clinical Oncology (ASCO), 2018 |
Medientyp: | unknown |
ISSN: | 1527-7755 (print) ; 0732-183X (print) |
DOI: | 10.1200/jco.2018.36.15_suppl.573 |
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