Somatic action potentials are sufficient for late-phase LTP-related cell signaling
In: Proceedings of the National Academy of Sciences, Jg. 99 (2002-03-12), S. 3962-3967
Online
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Zugriff:
A question of critical importance confronting neuroscientists today is how biochemical signals initiated at a synapse are conveyed to the nucleus. This problem is particularly relevant to the generation of the late phases of long-term potentiation (LTP). Here we provide evidence that some signaling pathways previously associated with late-LTP can be activated in hippocampal CA1 neurons without synaptic activity; somatic action potentials, induced by backfiring the cells, were found to be sufficient for phosphorylation of extracellular signal-regulated kinase-1/2 and cAMP response element-binding protein, as well as for induction of zif268 . Furthermore, such antidromic stimulation was adequate to rescue “tagged” synapses (early-LTP) from decay. These results show that a synapse-to-nucleus signal is not necessary for late-phase LTP-associated signaling cascades in the regulation of gene expression.
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Somatic action potentials are sufficient for late-phase LTP-related cell signaling
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Autor/in / Beteiligte Person: | R. Douglas Fields ; Dudek, Serena M. |
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Zeitschrift: | Proceedings of the National Academy of Sciences, Jg. 99 (2002-03-12), S. 3962-3967 |
Veröffentlichung: | Proceedings of the National Academy of Sciences, 2002 |
Medientyp: | unknown |
ISSN: | 1091-6490 (print) ; 0027-8424 (print) |
DOI: | 10.1073/pnas.062510599 |
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