Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes
In: Biochemistry and Cell Biology, Jg. 100 (2022-02-01), S. 1-8
Online
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Zugriff:
Secretory leukocyte protease inhibitor (SLPI) is a small but powerful member of the serine protease inhibitor family, which includes proteins such as elafin and α1-antitrypsin. These proteins all have similar structures and antiprotease abilities, but SLPI has been found to have an additional role as an anti-inflammatory factor. It can inhibit the production of pro-inflammatory cytokines in cells stimulated with lipopolysaccharide, prevent neutrophil infiltration in murine models of lung and liver injury, and regulate the activity of the transcription factor NF-κB. In this review, we will revisit SLPI’s unique biochemistry, and then explore how its anti-inflammatory functions can be linked to more recent findings showing that SLPI can localize to the nuclei of cells, bind DNA, and act as a regulator of gene expression.
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Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes
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Autor/in / Beteiligte Person: | Hannila, Sari S. ; Tinsley Claire Douglas |
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Zeitschrift: | Biochemistry and Cell Biology, Jg. 100 (2022-02-01), S. 1-8 |
Veröffentlichung: | Canadian Science Publishing, 2022 |
Medientyp: | unknown |
ISSN: | 1208-6002 (print) ; 0829-8211 (print) |
DOI: | 10.1139/bcb-2021-0284 |
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