Irregular Defects in Hepatocellular Carcinomas During the Kupffer Phase of Contrast-Enhanced Ultrasonography with Perfluorobutane Microbubbles: Pathological Features and Metastatic Recurrence After Surgical Resection
In: Ultrasound in Medicine & Biology, Jg. 43 (2017-09-01), S. 1829-1836
Online
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Zugriff:
The present study aimed to elucidate the association between post-vascular–phase (Kupffer-phase) images from contrast-enhanced ultrasonography (CEUS) with perfluorobutane microbubbles and metastatic recurrences after the resection of hepatocellular carcinoma (HCC). The study examined 73 patients with solitary HCC ≤5 cm in diameter who underwent CEUS before resection. HCC was defined as irregular type (including an irregular defect on Kupffer-phase images) or non-irregular type. Intrahepatic metastatic recurrence was defined as >3 intrahepatic recurrences. Metastatic recurrence included both extrahepatic and intrahepatic recurrences. Frequencies of microscopic portal invasion and intrahepatic metastasis were significantly higher in the irregular group than in the non-irregular group. Cumulative 5-y metastatic recurrence rates in the irregular and non-irregular groups were 43% and 7% (p = 0.028), respectively. Multivariate analyses identified Kupffer-phase findings as a factor significantly related to metastatic recurrence. In conclusion, HCCs with an irregular defect during Kupffer-phase CEUS are characterized by more frequent microscopic vascular invasion and intrahepatic metastasis and are significantly associated with metastatic recurrence after resection.
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Irregular Defects in Hepatocellular Carcinomas During the Kupffer Phase of Contrast-Enhanced Ultrasonography with Perfluorobutane Microbubbles: Pathological Features and Metastatic Recurrence After Surgical Resection
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Autor/in / Beteiligte Person: | Deguchi, Hisanobu ; Iguchi, Mikitaka ; Moribata, Kosaku ; Kato, Jun ; Shingaki, Naoki ; Shimizu, Ryo ; Ida, Yoshiyuki ; Yoshida, Takeichi ; Maekita, Takao ; Yamaue, Hiroki ; Ueno, Masaki ; Nuta, Junya ; Maeda, Yoshimasa ; Hayami, Shinya ; Fukatsu, Kazuhiro ; Tamai, Hideyuki ; Itonaga, Masahiro |
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Zeitschrift: | Ultrasound in Medicine & Biology, Jg. 43 (2017-09-01), S. 1829-1836 |
Veröffentlichung: | Elsevier BV, 2017 |
Medientyp: | unknown |
ISSN: | 0301-5629 (print) |
DOI: | 10.1016/j.ultrasmedbio.2017.04.023 |
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