Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease
In: Molecular Neurobiology, Jg. 51 (2014-06-24), S. 1158-1167
Online
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Zugriff:
Mitogen-activated protein kinase phosphatase (MKP)-1 provides a negative feedback mechanism for regulating mitogen-activated protein kinase (MAPK) activity and thus a variety of cellular processes such as proliferation, differentiation, growth and apoptosis. MKP-1 is established as a central regulator of a variety of functions in the immune, metabolic and cardiovascular systems, and it is now increasingly acknowledged as having a role to play in the nervous system. It has been implicated in regulating processes of neuronal cell development and death as well as in glial cell function. Reduced MKP-1 levels have been observed in models of neurological conditions including Huntington's disease, multiple sclerosis, ischemia and cerebral hypoxia. It has also been suggested to have a role to play in psychiatric disorders such as major depressive disorder. Here, we discuss the role of MKP-1 in nervous system development and disease and examine current evidence providing insight into MKP-1 as a potential therapeutic target for various diseases of the central nervous system.
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Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease
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Autor/in / Beteiligte Person: | Downer, Eric J. ; Toulouse, André ; Collins, Louise M. ; Nolan, Yvonne M. |
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Zeitschrift: | Molecular Neurobiology, Jg. 51 (2014-06-24), S. 1158-1167 |
Veröffentlichung: | Springer Science and Business Media LLC, 2014 |
Medientyp: | unknown |
ISSN: | 1559-1182 (print) ; 0893-7648 (print) |
DOI: | 10.1007/s12035-014-8786-6 |
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