Lamin A expression in circulating osteoprogenitors as a potential biomarker for frailty: The Nepean Osteoporosis and Frailty (NOF) Study
In: Experimental gerontology, Jg. 102 (2017-10-16)
Online
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Zugriff:
Lamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study. We quantified physical performance and disability, and stratified frailty in this population. Lamin A expression in epithelial and COP cells was quantified by flow cytometry. Linear regression models estimated the relationship between lamin A expression in buccal and COP cells, and prevalent disability and frailty. Lamin A expression in buccal cells showed no association with either disability or frailty. Low lamin A expression values in COP cells were associated with frailty. Frail individuals showed 60% lower levels of lamin A compared to non-frail (95% CI -36 to -74%, p
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Lamin A expression in circulating osteoprogenitors as a potential biomarker for frailty: The Nepean Osteoporosis and Frailty (NOF) Study
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Autor/in / Beteiligte Person: | Bermeo, Sandra ; Boersma, Derek ; Vogrin, Sara ; Duque, Gustavo ; Phu, Steven ; Suriyaarachchi, Pushpa ; Singh, Lakshman ; Ahmed Al Saedi ; Gunawardene, Piumali |
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Zeitschrift: | Experimental gerontology, Jg. 102 (2017-10-16) |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1873-6815 (print) |
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