Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling
In: Journal of the American Chemical Society, Jg. 142 (2020-05-11), S. 9604-9611
Online
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Zugriff:
A nickel-catalyzed, enantioselective, three-component fluoroalkylarylation of unactivated alkenes with aryl halides and perfluoroalkyl iodides has been described. This cross-electrophile coupling protocol utilizes a chiral nickel/BiOx system as well as a pendant chelating group to facilitate the challenging three-component, asymmetric difunctionalization of unactivated alkenes, providing direct access to valuable chiral β-fluoroalkyl arylalkanes with high efficiency and excellent enantioselectivity. The mild conditions allow for a broad substrate scope as well as good functional group toleration.
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Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling
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Autor/in / Beteiligte Person: | Chu, Lingling ; Qing, Feng-Ling ; Zhao, Xian ; Zhu, Shengqing ; Li, Yuanbo ; Wang, Fang ; Li, Huan ; Huo, Liping ; Tu, Hai-Yong |
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Zeitschrift: | Journal of the American Chemical Society, Jg. 142 (2020-05-11), S. 9604-9611 |
Veröffentlichung: | American Chemical Society (ACS), 2020 |
Medientyp: | unknown |
ISSN: | 1520-5126 (print) ; 0002-7863 (print) |
DOI: | 10.1021/jacs.0c03708 |
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