Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion
In: Nefrología (English Edition), Jg. 40 (2020), Heft 3, S. 311-319
Online
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Zugriff:
Background and aims: Renal ischemia-reperfusion occurs in some clinical conditions such as kidney surgery that can leads to acute renal failure. The aim of this study was to investigate the effect of p-coumaric acid (CA) on ischemia reperfusion (I/R) injury. Methods: Thirty rats were randomly divided into five groups; control, CA (100 mg/kg), I/R, propylene glycol (10%) + I/R and CA + I/R, (n = 6 each). CA and propylene glycol were administered orally for 2 weeks. Then, the rats were subjected to bilateral renal ischemia for 45 min and followed by reperfusion for 24 h. All rats were killed and kidney function tests, tissue malondialdehyde and activity of antioxidant enzymes were determined. Histopathological evaluations were also performed. In addition, renal expression of the tumor necrosis factor-α and interleukin-1β were determined using enzyme-linked immunosorbent assay and immunohistochemistry. Results: CA significantly improved the Cr and BUN levels in CA + I/R group compared to I/R group (p
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Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion
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Autor/in / Beteiligte Person: | Shahin Mozaffari Godarzi ; Mansouri, Esrafil ; Gholizadeh, Behnam ; Armita Valizade Gorji ; Seyyed Ali Mard |
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Zeitschrift: | Nefrología (English Edition), Jg. 40 (2020), Heft 3, S. 311-319 |
Veröffentlichung: | Elsevier, 2020 |
Medientyp: | unknown |
ISSN: | 2013-2514 (print) |
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