Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
In: Scientific Reports, Jg. 11 (2021), Heft 1, S. 1-14
Online
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Zugriff:
We investigated the clinical relevance of urinary cytokines/chemokines reflecting intrarenal immunologic micromilieu as prognostic markers and the optimal measurement timing after living donor kidney transplantation (LDKT). This prospective cohort study included 77 LDKT patients who were followed for ≥ 5 years. Patients were divided into control (n = 42) or acute rejection (AR, n = 35) group. Early AR was defined as AR occurring within 3 months. Serum and urine cytokines/chemokines were measured serially as follows: intraoperative, 8/24/72 h, 1 week, 3 months, and 1 year after LDKT. Intrarenal total leukocytes, T cells, and B cells were analyzed with immunohistochemistry followed by tissueFAXS. Urinary MCP-1 and fractalkine were also analyzed in a validation cohort. Urinary MCP-1 after one week was higher in the AR group. Urinary MCP-1, fractalkine, TNF-α, RANTES, and IL-6 after one week were significantly higher in the early AR group. Intrarenal total leukocytes and T cells were elevated in the AR group compared with the control group. Urinary fractalkine, MCP-1, and IL-10 showed positive correlation with intrarenal leukocyte infiltration. Post-KT 1 week urinary MCP-1 showed predictive value in the validation cohort. One-week post-KT urinary MCP-1 may be used as a noninvasive diagnostic marker for predicting AR after LDKT.
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Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
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Autor/in / Beteiligte Person: | Lee, Cheol-Jung ; Kim, Kyunga ; Jae Berm Park ; Huh, Wooseong ; Hye Ryoun Jang ; Jeon, Junseok ; Ghee Young Kwon ; Jung Eun Lee ; Dae Joong Kim ; Kim, Minjung ; Yoon Goo Kim ; Mee Yeon Park ; Lee, Kyungho ; Kyo Won Lee ; Hong, Sungjun ; Kyeong Eun Yang |
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Zeitschrift: | Scientific Reports, Jg. 11 (2021), Heft 1, S. 1-14 |
Veröffentlichung: | Springer Science and Business Media LLC, 2021 |
Medientyp: | unknown |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-021-98135-0 |
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