Synthesis of 1,5-benzothiazepine dipeptide mimetics via two CuI-catalyzed cross coupling reactions
In: Organic letters, Jg. 11 (2009-06-02), Heft 13
Online
unknown
Zugriff:
CuI-catalyzed coupling of 4-methylphenyl bromide with amino acids gives N-aryl amino acids, which are converted into linear dipeptides via iodination and condensation with l-cysteine derived acyl chloride. Cyclization is achieved via a CuI/N,N-dimethylglycine catalyzed intramolecular coupling of aryl iodides with the liberated thiol to afford 1,5-benzothiazepine dipeptide mimetics.
Titel: |
Synthesis of 1,5-benzothiazepine dipeptide mimetics via two CuI-catalyzed cross coupling reactions
|
---|---|
Autor/in / Beteiligte Person: | Ma, Dawei ; Gan, Jiangang |
Link: | |
Zeitschrift: | Organic letters, Jg. 11 (2009-06-02), Heft 13 |
Veröffentlichung: | 2009 |
Medientyp: | unknown |
ISSN: | 1523-7052 (print) |
Schlagwort: |
|
Sonstiges: |
|