Associations of HLA-DRB1 and -DQB1 alleles with severe recurrent respiratory papillomatosis in Korean patients
In: Human Immunology, Jg. 74 (2013-08-01), S. 961-964
Online
unknown
Zugriff:
Recurrent respiratory papillomatosis (RRP) is characterized by frequent recurrences of papilloma of the larynx with significant morbidity. It is caused by human papillomavirus (HPV) types 6 and 11. Some associations of HLA genes with RRP have been reported, mainly in Caucasians. We performed HLA class II (DRB1 and DQB1) genotyping using Dynal RELI™ HLA-DRB1 SSO kit and PCR-single strand conformation polymorphism on 22 Korean patients with severe RRP and 207 healthy controls. The gene frequencies of HLA-DRB1*11:01 (18.2% vs 3.6%, p = 0.0006, p c = 0.02, odds ratio [OR] = 5.9) and DQB1*03:01 (36.4% vs 14.5%, p = 0.0009, p c = 0.01, OR = 3.4) and the haplotype frequency of DRB1*11:01-DQB1*03:01 (15.9% vs 3.6%, p = 0.003, OR = 5.0) was higher in RRP patients than controls. DRB1*11:01 and DRB1*11:01-DQB1*03:01 haplotype were strongly associated with disease susceptibility to severe RRP in Koreans.
Titel: |
Associations of HLA-DRB1 and -DQB1 alleles with severe recurrent respiratory papillomatosis in Korean patients
|
---|---|
Autor/in / Beteiligte Person: | Eun Young Song ; Tack Kyun Kwon ; Kyoung Un Park ; Myoung Hee Park ; Sung, Myung-Whun ; Kwang Hyun Kim ; Shin, Sue |
Link: | |
Zeitschrift: | Human Immunology, Jg. 74 (2013-08-01), S. 961-964 |
Veröffentlichung: | Elsevier BV, 2013 |
Medientyp: | unknown |
ISSN: | 0198-8859 (print) |
DOI: | 10.1016/j.humimm.2013.04.020 |
Schlagwort: |
|
Sonstiges: |
|