Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF −/− mice
In: Proceedings of the National Academy of Sciences, Jg. 111 (2014-03-17), S. 4964-4969
Online
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Zugriff:
Tata Element Modulatory Factor (TMF/ARA160) is a multifunctional Golgi-associated protein, which accumulates in colonic enterocytes and goblet cells. Mice lacking TMF/ARA160 (TMF(-/-)) produce thick and uniform colonic mucus that resists adherent bacterial colonization and diminishes susceptibility of these mice to induced acute colitis, through a mechanism that is not fully understood. Here, we show that mucus secretion by goblet cells is altered in the colon of TMF(-/-) mice, resulting in the formation of a highly oligomerized colonic gel-forming mucin, MUC2. Microbiome analysis revealed a shift in the microbiota of TMF(-/-) mice leading to predominance of the Firmicutes phylum and a significantly higher abundance of probiotic beneficial bacterial species. Notably, this trait was transmissible, and when cohoused with wild-type animals, TMF(-/-) mice influenced the microbiota and diminished the susceptibility of wild-type mice to chemically induced dextran sulfate sodium colitis. Thus, altered mucus secretion in TMF(-/-) mouse colons is accompanied by a reprogrammed intestinal microbiota, leading to a transmissible reduced sensitivity to induced colitis.
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Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF −/− mice
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Autor/in / Beteiligte Person: | Bel, Shai ; Elifantz, Hila ; Ben-Hamo, Rotem ; Elkis, Yoav ; Koren, Omry ; Nyska, Abraham ; Nir, Uri ; Lerer-Goldshtein, Tal ; Rahimi, Roni ; Shpungin, Sally ; Shomron Ben Horin |
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Zeitschrift: | Proceedings of the National Academy of Sciences, Jg. 111 (2014-03-17), S. 4964-4969 |
Veröffentlichung: | Proceedings of the National Academy of Sciences, 2014 |
Medientyp: | unknown |
ISSN: | 1091-6490 (print) ; 0027-8424 (print) |
DOI: | 10.1073/pnas.1319114111 |
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