Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study
In: Experimental and therapeutic medicine, Jg. 12 (2016-08-11), Heft 5
Online
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Zugriff:
In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were enrolled in this retrospective study. Fifty-nine patients in the HES group received 6% HES 130/0.4 combined with crystalloid solution for fluid resuscitation (HES group). In the control group, 61 patients received only crystalloid solution after admission. Interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor (TNF)-α levels in serum were measured on days 1, 2, 4 and 8. The peripheral blood CD4+CD8+ T lymphocyte rates, serum BUN and Cr values were also measured on days 1, 4 and 8. Patients with FB(-) rates were recorded from day 1 to 8. Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-α in the HES group compared with the control group. The difference in curve's risk ratio was not significant for IL-6, CD4+CD8+ T lymphocyte rate, BUN and Cr values (P>0.05). In the HES group, we detected a significantly higher rate of patients with FB(-) from day 4 to 8 (P
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Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study
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Autor/in / Beteiligte Person: | Chen, Chang-Zhong ; Dong, Liming ; Yang, Hongji ; Wang, Chunyou ; Chen, Qi-Jun ; Wu, Heshui ; Yang, Chong ; Yang, Zhiyong ; Zhu, Shikai ; Zhang, Yushun ; Xie, Chao |
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Zeitschrift: | Experimental and therapeutic medicine, Jg. 12 (2016-08-11), Heft 5 |
Veröffentlichung: | 2016 |
Medientyp: | unknown |
ISSN: | 1792-0981 (print) |
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