The LCT 13910 C/T polymorphism as a risk factor for osteoporosis, has no impact on metastatic bone disease in breast cancer
In: Breast Cancer Research and Treatment, Jg. 112 (2007-12-15), S. 363-365
Online
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Zugriff:
To the editorThe most common skeletal complication of breast can-cer is bone metastasis, which occurs in 80% of patientswith advanced disease [1, 2].The maintenance of skeletal integrity in a healthyindividual requires a balanced bone remodeling. Osteo-clast-mediated bone resorption is a common factor in thepathogenesis of osteoporosis and metastatic bone disease[3, 4]. Evidence is given, that tumor mediated osteoclastactivation disrupts the normal equilibrium of boneremodeling, allowing tumor cells to survive and grow inthis microenvironment [4, 5].A functional dimorphism, 13910 C/T (LCT) which isassociated with adult lactose intolerance, has been sug-gested as a possible risk factor for osteoporosis and bonefractures, particularly in postmenopausal women [6].In the present study, we investigated the impact of the13910 C/T LCT polymorphism on the risk of bonemetastasis in 500 breast cancer patients. Patient charac-teristics have been described previously [7]. The study wasperformed according to the Austrian Gene Technology Actand had been approved by the local ethics committee.Written informed consent was obtained from all subjects.LCT -13910 genotypes were determined as describedpreviously [7]. SPSS 14.0 for Windows was used for sta-tistical analysis. Continuous values were analyzed byStudent’s t-test, and proportions of groups compared by the
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The LCT 13910 C/T polymorphism as a risk factor for osteoporosis, has no impact on metastatic bone disease in breast cancer
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Autor/in / Beteiligte Person: | Clar, Heimo ; Langsenlehner, Tanja ; Langsenlehner, U. ; Hofmann, Guenter ; Renner, Wilfried ; Leithner, Andreas ; Yazdani-Biuki, B. ; Windhager, Reinhard ; Krippl, Peter ; Clar, V. ; Gruber, Gerald |
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Zeitschrift: | Breast Cancer Research and Treatment, Jg. 112 (2007-12-15), S. 363-365 |
Veröffentlichung: | Springer Science and Business Media LLC, 2007 |
Medientyp: | unknown |
ISSN: | 1573-7217 (print) ; 0167-6806 (print) |
DOI: | 10.1007/s10549-007-9863-6 |
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