Three‐Component Perfluoroalkylvinylation of Alkenes Enabled by Dual DBU/Fe Catalysis**
In: Chemistry – A European Journal, Jg. 29 (2022-12-14)
Online
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Zugriff:
Herein, a simple and efficient strategy that involves dual 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)/iron-catalyzed alkene perfluoroalkylvinylation by using perfluoroalkyl iodides and 2-aminonaphthalene-1,4-diones as coupling partners is demonstrated. In terms of the developed catalytic system, various styrenes and aliphatic alkenes are well-tolerated, leading to the accurate preparation of perfluoroalkyl-containing 2-aminonaphthalene-1,4-diones in excellent regioselectivity. Moreover, the protocol can be readily applied in late-stage modifications of natural products and pharmaceuticals. The title reactions are featured by easily accessible and inexpensive catalysts and substrates, broad substrate applicability, and mild reaction conditions. Mechanistic investigations reveal a tandem C-I cleavable alkylation and C-C vinylation enabled by cooperative DBU/iron catalysis.
Titel: |
Three‐Component Perfluoroalkylvinylation of Alkenes Enabled by Dual DBU/Fe Catalysis**
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Autor/in / Beteiligte Person: | Tang, Lin ; Lv, Ge ; Cheng, Ruimin ; Yang, Fang ; Zhou, Qiuju |
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Zeitschrift: | Chemistry – A European Journal, Jg. 29 (2022-12-14) |
Veröffentlichung: | Wiley, 2022 |
Medientyp: | unknown |
ISSN: | 1521-3765 (print) ; 0947-6539 (print) |
DOI: | 10.1002/chem.202203332 |
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