Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
In: Nature Communications, Jg. 12 (2021), Heft 1, S. 1-22
Online
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Zugriff:
Basal progenitors (BPs), including intermediate progenitors and basal radial glia, are generated from apical radial glia and are enriched in gyrencephalic species like humans, contributing to neuronal expansion. Shortly after generation, BPs delaminate towards the subventricular zone, where they further proliferate before differentiation. Gene expression alterations involved in BP delamination and function in humans are poorly understood. Here, we study the role of LGALS3BP, so far known as a cancer biomarker, which is a secreted protein enriched in human neural progenitors (NPCs). We show that individuals with LGALS3BP de novo variants exhibit altered local gyrification, sulcal depth, surface area and thickness in their cortex. Additionally, using cerebral organoids, human fetal tissues and mice, we show that LGALS3BP regulates the position of NPCs. Single-cell RNA-sequencing and proteomics reveal that LGALS3BP-mediated mechanisms involve the extracellular matrix in NPCs’ anchoring and migration within the human brain. We propose that its temporal expression influences NPCs’ delamination, corticogenesis and gyrification extrinsically.
Nature Communications, 12
ISSN:2041-1723
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Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
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| Autor/in / Beteiligte Person: | He, Zhisong ; Lenge, Matteo ; Coquand, Laure ; Pierpaolo D' Andrea ; Sieber, Stephan A. ; O’Neill, Adam C. ; Mei, Davide ; Cappello, Silvia ; Kyrousi, Christina ; Rossella Di Giaimo ; Robertson, Stephen P. ; Alexandre D Baffet ; Buchsbaum, Isabel Y. ; Andrea Forero Echeverry ; Fabien, Guimiot ; Cruceanu, Cristiana ; Kielkowski, Pavel ; Brazovskaja, Agnieska ; Binder, Elisabeth B. ; Treutlein, Barbara ; Guerrini, Renzo ; Belka, Alexander ; Khattak, Shahryar ; Elmslie, Frances ; Max Planck Institute of Psychiatry ; Max-Planck-Gesellschaft ; National and Kapodistrian University of Athens (NKUA) ; University of Otago [Dunedin, Nouvelle-Zélande] ; Max Planck Institute for Evolutionary Anthropology [Leipzig] ; Department of Biosystems Science and Engineering [ETH Zürich] (D-BSSE) ; Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich) ; Center for Integrated Protein Science (CIPSM) ; Technical University of Munich (TUM)-Helmholtz-Zentrum München (HZM)-Ludwig Maximilian University of Munich [Germany] (LMU München) ; Ludwig-Maximilians-Universität München (LMU) ; Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP) ; Institut Curie [Paris] ; University of Naples Federico, II ; Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI) ; Technische Universität Dresden = Dresden University of Technology (TU Dresden) ; Royal College of Surgeons in Ireland (RCSI) ; Hôpital Robert Debré ; University of London [London] ; O'Neill, Adam C ; Di Giaimo, Rossella ; D' Andrea, Pierpaolo ; Forero Echeverry, Andrea ; Buchsbaum, Isabel Y ; Binder, Elisabeth ; Elmslie, France ; Baffet, Alexandre D ; Sieber, Stephan A ; Robertson, Stephen P ; Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Helmholtz-Zentrum München (HZM)-Ludwig Maximilian University of Munich [Germany] (LMU München) |
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| Zeitschrift: | Nature Communications, Jg. 12 (2021), Heft 1, S. 1-22 |
| Veröffentlichung: | 2021 |
| Medientyp: | unknown |
| ISSN: | 2041-1723 (print) |
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