Sirolimus- versus paclitaxel-eluting stents for coronary bifurcations intervention
In: Catheterization and Cardiovascular Interventions, Jg. 80 (2011-11-01), S. 507-513
Online
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Zugriff:
Backgrounds: Relative efficacy and safety of sirolimus-eluting stents (SES) compared with paclitaxel-eluting stents (PES) remains controversial. It is unknown whether there are different effect and safety in coronary bifurcation treatment between SES and PES. Objectives: The meta-analysis was performed to compare the clinical outcomes of SES and PES in coronary bifurcation intervention. Methods: Five head-to-head clinical trials of SES versus PES in coronary bifurcation intervention were included. A total of 2,567 patients were involved in the meta-analysis. Mean follow-up period ranged from 6 to 35 months. The primary end points were the need for target lesion revascularization (TLR) and main-branch restenosis. Secondary end points were target vessel revascularization (TVR), cardiac death, major adverse cardiac events (MACE), and stent thrombosis. Results: Compared with PES, SES significantly reduced the risk of TLR (5.3% vs. 10.6%, odds ratio (OR) 0.52; 95% confidence interval (CI) = 0.38–0.70, P < 0.001), main-branch restenosis (4.59% vs. 12.59%, OR 0.31; 95% CI = 0.18–0.55, P < 0.001) and TVR (7.05% vs. 12.57%, OR 0.58; 95% CI = 0.42–0.81, P = 0.001) in coronary bifurcation intervention. In addition, SES group also had a significantly lower incidence of MACE (8.20% vs. 14.13%, OR 0.58; 95% CI = 0.40–0.84, P = 0.004) than PES group. However, there were no statistical difference with respect to the incidence of cardiac death (1.64% vs. 1.09%, P = 0.19) and stent thrombosis (0.84% vs. 1.08%, P = 0.64) between SES and PES groups. Conclusions: Compared with PES, SES reduced the incidence of TLR, main-branch restenosis and MACE in coronary bifurcation intervention, while the risk of stent thrombosis was similar between SES and PES groups. © 2011 Wiley Periodicals, Inc.
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Sirolimus- versus paclitaxel-eluting stents for coronary bifurcations intervention
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Autor/in / Beteiligte Person: | Qian, Juying ; Chen, Zhangwei ; Ma, Jianying ; Ge, Junbo |
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Zeitschrift: | Catheterization and Cardiovascular Interventions, Jg. 80 (2011-11-01), S. 507-513 |
Veröffentlichung: | Wiley, 2011 |
Medientyp: | unknown |
ISSN: | 1522-1946 (print) |
DOI: | 10.1002/ccd.23392 |
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