Association of molecular subtype, proliferation, and immune genes with efficacy of carboplatin versus gemcitabine addition to taxane-based, anthracycline-free neoadjuvant chemotherapy in early triple-negative breast cancer (TNBC): Results of the randomized WSG ADAPT-TN trial
In: Journal of Clinical Oncology, Jg. 35 (2017-05-20), S. 573-573
Online
unknown
Zugriff:
573 Background: In the ADAPT-TN neoadjuvant trial, 12-week nab-paclitaxel (nab- pac)+carboplatin (carbo) was highly effective and superior to nab-pac+gemcitabine (gem). However, within TNBC, reliable predictive markers for carbo use have yet to be identified. Methods: Patients with early TNBC (centrally confirmed) were treated by nab-pac 125 mg/m2 with either carbo AUC2 or gem 1000 mg/m2 d 1,8 q21 given for 4 cycles. Genomic data (80 genes) and Prosigna (PAM-50) scores were available in 306 pre-therapeutic samples of 331 treated patients. Fisher’s exact test was performed for pCR differences; associations of continuous measurements or scores with pCR were analyzed by the Mann-Whitney statistic. Results: pCR was 44.5% to 28.4% (p=.004) in favor of nab-pac - carbo. Specifically within the carbo- containing arm, immunological (CD8, PD1, PFDL1) genes and proliferation markers (proliferation score and ROR scores, MKI67, CDC20, NUF2, KIF2C, CENPF, EMP3, TYMS) were positively associated with pCR (p
Titel: |
Association of molecular subtype, proliferation, and immune genes with efficacy of carboplatin versus gemcitabine addition to taxane-based, anthracycline-free neoadjuvant chemotherapy in early triple-negative breast cancer (TNBC): Results of the randomized WSG ADAPT-TN trial
|
---|---|
Autor/in / Beteiligte Person: | Hackmann, John ; Gebauer, Daniel ; Kümmel, Sherko ; Liedtke, Cornelia ; Warm, Mathias ; Aktas, Bahriye ; Kates, Ronald E. ; Kreipe, Hans ; Pelz, E ; Harbeck, Nadia ; Christgen, Matthias ; Forstbauer, Helmut ; Grischke, Eva-Maria ; Wuerstlein, Rachel ; Gluz, Oleg ; Schumacher, Claudia ; Uleer, Christoph ; Nitz, Ulrike ; Prat, Aleix ; Braun, Michael |
Link: | |
Zeitschrift: | Journal of Clinical Oncology, Jg. 35 (2017-05-20), S. 573-573 |
Veröffentlichung: | American Society of Clinical Oncology (ASCO), 2017 |
Medientyp: | unknown |
ISSN: | 1527-7755 (print) ; 0732-183X (print) |
DOI: | 10.1200/jco.2017.35.15_suppl.573 |
Schlagwort: |
|
Sonstiges: |
|