Generation of CCM Phenotype by a Human Microvascular Endothelial Model
In: Methods in Molecular Biology ISBN: 9781071606391; (2020)
Online
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Zugriff:
Cerebral cavernous malformations (CCMs) is a disorder of endothelial cells predominantly localized in the brain. Although a complete inactivation of each CCM protein has been found in the affected endothelium of diseased patients and a necessary and additional role of microenvironment has been demonstrated to determine in vivo the occurrence of vascular lesions, a microvascular endothelial model based on knockdown of a CCM gene represents today a convenient method to study some of critical signaling events regulating pathogenesis of CCM. For these reasons, in our laboratory we developed a microvascular cerebral endothelial model of Krit1 deficiency performing silencing experiments of CCM1 gene (Krit1) with siRNA procedure.
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Generation of CCM Phenotype by a Human Microvascular Endothelial Model
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Autor/in / Beteiligte Person: | Simona Delle Monache ; Saverio Francesco Retta |
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Quelle: | Methods in Molecular Biology ISBN: 9781071606391; (2020) |
Veröffentlichung: | Humana Press, 2020 |
Medientyp: | unknown |
ISBN: | 978-1-0716-0639-1 (print) |
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