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Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functional magnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomarkers and predictors of TBI outcome. This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties at the level of the connectome. In this context, our present review summarizes recent developments on the roles of these two techniques in the search for novel structural neuroimaging biomarkers that have TBI outcome prognostication value. The themes being explored cover notable trends in this area of research, including (1) the role of advanced MRI processing methods in the analysis of structural pathology, (2) the use of brain connectomics and network analysis to identify outcome biomarkers, and (3) the application of multivariate statistics to predict outcome using neuroimaging metrics. The goal of the review is to draw the community's attention to these recent advances on TBI outcome prediction methods and to encourage the development of new methodologies whereby structural neuroimaging can be used to identify biomarkers of TBI outcome.

Highlights ► MRI/DTI processing methods are becoming increasingly prominent in TBI research. ► Brain connectomics and network analysis may offer useful biomarkers of TBI outcome. ► Multivariate statistics offers useful ways to identify biomarkers of TBI evolution.

Titel:	Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction
Autor/in / Beteiligte Person:	Vespa, Paul M. ; Aylward, Stephen R. ; Prastawa, Marcel ; Irimia, Andrei ; Wang, Bo ; John D. Van Horn ; Kikinis, Ron ; Pace, Danielle F. ; Gerig, Guido ; Hovda, David A.
Link:	View record in OpenAIRE (Volltext) https://escholarship.org/uc/item/73g5450t
Quelle:	NeuroImage. Clinical, vol 1, iss 1 NeuroImage : Clinical; (2012)
Veröffentlichung:	eScholarship, University of California, 2012
Medientyp:	unknown
Schlagwort:	Pathology SPM Review Article diffuse axonal injury 0302 clinical medicine ADC, apparent diffusion coefficient DSI TBI three-dimensional FA, fractional anisotropy Fluid Attenuated Inversion Recovery PCA traumatic brain injury fMRI ANTS, Advanced Normalization ToolS GM diffusion tensor imaging TBSS CT, computed tomography BOLD, blood oxygen level dependent Neurology fMRI, functional magnetic resonance imaging DTI GRE tract-based spatial statistics Connectome apparent diffusion coefficient Biomedical Imaging FLAIR, Fluid Attenuated Inversion Recovery medicine.medical_specialty Connectomics NINDS Physical Injury - Accidents and Adverse Effects LDA ANTS CC, corpus callosum GOS, Glasgow Outcome Score Traumatic Brain Injury (TBI) Trauma TBI, traumatic brain injury 03 medical and health sciences Clinical Research diffusion weighted imaging WM, white matter NINDS, National Institute of Neurological Disorders and Stroke Traumatic Head and Spine Injury Diffusion tensor 3D, three-dimensional computed tomography GCS medicine.disease blood oxygen level dependent TBSS, tract-based spatial statistics GM, gray matter PROspective MOtion Correction DTI, diffusion tensor imaging Neurology (clinical) Functional magnetic resonance imaging Outcome prediction diffusion spectrum imaging Neuroscience 030217 neurology & neurosurgery Diffusion MRI BOLD linear discriminant analysis principal component analysis Susceptibility Weighted Imaging DWI FSE Outcome measures PROMO, PROspective MOtion Correction 030218 nuclear medicine & medical imaging corpus callosum HARDI FLAIR magnetic resonance imaging Pediatric screening and diagnosis Advanced Normalization ToolS IBA, Individual Brain Atlas medicine.diagnostic_test HARDI, high-angular-resolution diffusion imaging AAL Gradient Recalled Echo Statistical Parametric Mapping gray matter CC Childhood Injury DSI, diffusion spectrum imaging Detection Neurological National Institute of Neurological Disorders and Stroke IBA Psychology white matter fractional anisotropy GCS, Glasgow Coma Score SWI, Susceptibility Weighted Imaging 3D CT MRI Individual Brain Atlas FA Traumatic brain injury Cognitive Neuroscience Context (language use) Neuroimaging GRE, Gradient Recalled Echo Glasgow Outcome Score MRI/fMRI FSE, Functional Status Examination AAL, Automatic Anatomical Labeling medicine SWI Radiology, Nuclear Medicine and imaging Automatic Anatomical Labeling WM high-angular-resolution diffusion imaging PCA, principal component analysis Glasgow Coma Score DWI, diffusion weighted imaging GOS DAI Neurosciences SPM, Statistical Parametric Mapping Functional Status Examination DAI, diffuse axonal injury functional magnetic resonance imaging Brain Disorders 4.1 Discovery and preclinical testing of markers and technologies ADC MRI, magnetic resonance imaging PROMO LDA, linear discriminant analysis
Sonstiges:	Nachgewiesen in: OpenAIRE File Description: application/pdf Rights: OPEN

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Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction