Alteration in chondroitin sulfate proteoglycan expression at the epicenter of spinal cord is associated with the loss of behavioral function in Tiptoe walking Yoshimura mice
In: Neurochemical research, Jg. 39 (2014-04-08), Heft 12
Online
unknown
Zugriff:
The objective of this study was to explore the correlation between the alteration in chondroitin sulfate proteoglycan (CSPG) expression at the epicenter of spinal cord and the loss of behavioral function in tiptoe walking Yoshimura mice. The tiptoe walking Yoshimura mice (twy) and Institute of Cancer Research (ICR) mice, aged 20 and 26 weeks, were used in the present study. The behavior assessment, micro-computed tomography and immunofluorescent staining were performed. The compressed spinal cord was histologically analyzed. The results showed that the expression of CSPG was statistically higher at the compressed spinal cord for twy mice compared with that at the normal spinal cord for ICR mice. At the 26th week, a large ossification block at the posterior longitudinal ligament of C1-3 was obviously observed at the micro-CT image We observed the BMS Score was significantly correlated with the expression of glial fibrillary acidic protein, CSPG and hyaluronan (P
Titel: |
Alteration in chondroitin sulfate proteoglycan expression at the epicenter of spinal cord is associated with the loss of behavioral function in Tiptoe walking Yoshimura mice
|
---|---|
Autor/in / Beteiligte Person: | Lv, Jia ; Wang, Xiaofang ; Wang, Jun ; Wei, Feng ; Rong, Wei ; Liu, Zhongjun |
Link: | |
Zeitschrift: | Neurochemical research, Jg. 39 (2014-04-08), Heft 12 |
Veröffentlichung: | 2014 |
Medientyp: | unknown |
ISSN: | 1573-6903 (print) |
Schlagwort: |
|
Sonstiges: |
|