Similarity in viral and host promoters couples viral reactivation with host cell migration
In: Nature Communications Nature Communications, Jg. 8 (2017), Heft 1, S. 1-11
Online
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Zugriff:
Viral–host interactomes map the complex architecture of an evolved arms race during host cell invasion. mRNA and protein interactomes reveal elaborate targeting schemes, yet evidence is lacking for genetic coupling that results in the co-regulation of promoters. Here we compare viral and human promoter sequences and expression to test whether genetic coupling exists and investigate its phenotypic consequences. We show that viral–host co-evolution is imprinted within promoter gene sequences before transcript or protein interactions. Co-regulation of human immunodeficiency virus (HIV) and human C-X-C chemokine receptor-4 (CXCR4) facilitates migration of infected cells. Upon infection, HIV can actively replicate or remain dormant. Migrating infected cells reactivate from dormancy more than non-migrating cells and exhibit differential migration–reactivation responses to drugs. Cells producing virus pose a risk for reinitiating infection within niches inaccessible to drugs, and tuning viral control of migration and reactivation improves strategies to eliminate latent HIV. Viral–host genetic coupling establishes a mechanism for synchronizing transcription and guiding potential therapies.
The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.
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Similarity in viral and host promoters couples viral reactivation with host cell migration
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Autor/in / Beteiligte Person: | Bohn-Wippert, Kathrin ; Tevonian, Erin N. ; Dar, Roy D. ; Megaridis, Melina R. |
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Zeitschrift: | Nature Communications Nature Communications, Jg. 8 (2017), Heft 1, S. 1-11 |
Veröffentlichung: | Nature Publishing Group, 2017 |
Medientyp: | unknown |
ISSN: | 2041-1723 (print) |
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