Late cytomegalovirus pneumonia in adult allogeneic blood and marrow transplant recipients
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jg. 28 (1999-04-08), Heft 3
Online
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Zugriff:
To assess the impact of antiviral prophylaxis during the first 3 months after transplantation on the frequency, timing, and outcome of cytomegalovirus (CMV) pneumonia during the first year, 541 adult allogeneic blood and marrow transplant recipients were evaluated. Thirty-four patients (6.3%) developed 35 episodes of CMV pneumonia at a mean of 188 days after transplantation, with an associated mortality rate of 76%. Twenty-six episodes (74%) occurred late (after day 100). Of the patients with late CMV pneumonia almost all (92%) had chronic graft vs. host disease or had received T cell-depleted transplants. Fourteen late CMV pneumonias (54%) were associated with serious concurrent infections, and 100% of these episodes were fatal. In conclusion, although the frequency of CMV pneumonia in the early posttransplantation period may be substantially reduced by prophylaxis, CMV continues to be a major cause of morbidity and mortality in the late period. Some subsets of patients need more prolonged surveillance and prophylaxis and/or preemptive therapy.
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Late cytomegalovirus pneumonia in adult allogeneic blood and marrow transplant recipients
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Autor/in / Beteiligte Person: | Nguyen, Quynh-Nhu ; Ippoliti, Cindy ; Champlin, Richard E. ; Giralt, Sergio ; Luna, Mario A. ; Jacobson, K. ; Hecht, D. ; Rolston, Kenneth V. I. ; Tarrand, Jeffrey J. ; Whimbey, Estella ; Issam I Raad |
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Zeitschrift: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jg. 28 (1999-04-08), Heft 3 |
Veröffentlichung: | 1999 |
Medientyp: | unknown |
ISSN: | 1058-4838 (print) |
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