Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin
In: Transplant International, Jg. 2 (1989-08-01), S. 92-95
Online
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Zugriff:
In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified.
Titel: |
Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin
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Autor/in / Beteiligte Person: | Koene, R. A. P. ; Janssen, Henk P. ; Bosch, F. H. ; A. M. van Loon ; Hoitsma, A. J. |
Link: | |
Zeitschrift: | Transplant International, Jg. 2 (1989-08-01), S. 92-95 |
Veröffentlichung: | Springer Science and Business Media LLC, 1989 |
Medientyp: | unknown |
ISSN: | 1432-2277 (print) ; 0934-0874 (print) |
DOI: | 10.1007/bf02459326 |
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