Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions
In: Virology, Jg. 346 (2006-03-01), S. 373-378
Online
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Zugriff:
Human endogenous retroviruses (HERVs) occupy about 5% of human DNA and are thought to be remnants of ancient retroviral infections of human ancestors' germ cells. HERVs can modify expression of host cell genes through their cis-regulatory elements concentrated in their long terminal repeats (LTRs). Although numerous HERV-related RNAs were identified in the human transcriptome, for most of them, it remains unclear whether they are LTR-promoted or read-through products initiated from neighboring genomic promoters. Here, we describe mapping of transcriptional start sites within solitary and proviral LTRs of the HERV-K (HML-2) human-specific subfamily of endogenous retroviruses. Surprisingly, the transcription was initiated predominantly from the very 3′ termini of the LTR R regions. The data presented here may shed light on adaptive coevolution of human endogenous retroviruses with their host cells.
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Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions
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Autor/in / Beteiligte Person: | Gogvadze, Elena ; Buzdin, Anton ; Vinogradova, Tatyana V. ; Sverdlov, Eugene D. ; Kovalskaya, Elena |
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Zeitschrift: | Virology, Jg. 346 (2006-03-01), S. 373-378 |
Veröffentlichung: | Elsevier BV, 2006 |
Medientyp: | unknown |
ISSN: | 0042-6822 (print) |
DOI: | 10.1016/j.virol.2005.11.007 |
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