A novel myeloid cell line, Marimo, derived from therapy-related acute myeloid leukemia during treatment of essential thrombocythemia: Consistent chromosomal abnormalities and temporary C-MYC gene amplification
In: Cancer Genetics and Cytogenetics, Jg. 100 (1998), S. 21-24
Online
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Zugriff:
A novel myeloid leukemia cell line, Marimo, was established from bone marrow cells of a patient with secondary acute myeloid leukemia (AML) that had developed during the treatment of essential thrombocythemia (ET) with busulfan. Karyotype at the ET phase was 46,XX,der(15)t(1;15) (q23;p12-13), but at the blastic phase changed to 44,XX,-5,del(8)(q22), add(17)(p11),+18, psu dic(18;9) (q23;p21) x 2 lacking t(1;15). In Marimo cells, C-MYC gene was temporarily amplified by double-minutes (dmin) but disappeared at 33 months, whereas t(10;14;11)(q22;q32;q13) and t(10;14)(q22;q32) were added in vitro psu dic(18;9) x 2 and add(17)(p11) were consistently found throughout the culture. These results suggest that this AML clone is not derived from ET but rather is therapy-related.
Titel: |
A novel myeloid cell line, Marimo, derived from therapy-related acute myeloid leukemia during treatment of essential thrombocythemia: Consistent chromosomal abnormalities and temporary C-MYC gene amplification
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Autor/in / Beteiligte Person: | Ichihashi, Takuji ; Ohno, Ryuzo ; Hashimoto, Naoya ; Naoe, Tomoki ; Inazawa, Joji ; Yoshida, Hitoshi ; Kondo, Makoto |
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Zeitschrift: | Cancer Genetics and Cytogenetics, Jg. 100 (1998), S. 21-24 |
Veröffentlichung: | Elsevier BV, 1998 |
Medientyp: | unknown |
ISSN: | 0165-4608 (print) |
DOI: | 10.1016/s0165-4608(97)00017-4 |
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