Susceptibility to Experimental Lyme Arthritis Correlates with KC and Monocyte Chemoattractant Protein-1 Production in Joints and Requires Neutrophil Recruitment Via CXCR2
In: The Journal of Immunology, Jg. 171 (2003-07-15), S. 893-901
Online
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Zugriff:
The development of experimental Lyme arthritis has been correlated with the expression of a number of chemokines and cytokines, however, none of these have been measured directly from the arthritic joint. We examined the temporal expression of IL-1β, IL-4, IL-6, IL-10, IL-12p70, GM-CSF, IFN-γ, TNF-α, macrophage inflammatory protein-2, KC, macrophage inflammatory protein-1α, and monocyte chemoattractant protein-1 directly from the tibiotarsal joint in arthritis-resistant C57BL/6 (B6) and -susceptible C3H/He (C3H) mice. Only the chemokines KC and monocyte chemoattractant protein-1 were differentially expressed in joints of B6 and C3H mice and correlated with the development of Lyme arthritis. Infection of CXCR2−/− mice on either genetic background resulted in a significant decrease in the development of pathology, although infection of CCR2−/− mice had little or no effect. Neutrophils in CXCR2−/− mice were marginalized within blood vessels and could not enter the joint tissue. These results suggest that chemokine-mediated recruitment of neutrophils into the infected joint is a key requirement for the development of experimental Lyme arthritis.
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Susceptibility to Experimental Lyme Arthritis Correlates with KC and Monocyte Chemoattractant Protein-1 Production in Joints and Requires Neutrophil Recruitment Via CXCR2
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Autor/in / Beteiligte Person: | Brown, Charles R. ; Loiacono, Christie M. ; Blaho, Victoria A. |
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Zeitschrift: | The Journal of Immunology, Jg. 171 (2003-07-15), S. 893-901 |
Veröffentlichung: | The American Association of Immunologists, 2003 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) ; 0022-1767 (print) |
DOI: | 10.4049/jimmunol.171.2.893 |
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