Activation ofgef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection
In: International Journal of Cancer, Jg. 113 (2004), S. 533-540
Online
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Zugriff:
Several oncogenes isolated by the NIH/3T3 transformation assay, i.e., dbl, dbs, lbc, lfc, lsc, net, ost and tim, contain a Dbl homology (DH) and a pleckstrin-homology (PH) domain and act as GEFs (guanine nucleotide exchange factors) for Rho-like GTPases. In a search for genes with oncogenic potential in DNA from the monocytic leukaemia cell line U937, we identified an amino-terminal truncated form of gef-h1, a gene encoding a GEF for RhoA. These data support the idea that a systematic search for mutations and/or deletions of GEFs in human cancer is promising.
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Activation ofgef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection
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Autor/in / Beteiligte Person: | Luf, Susanne ; Johannes W.G. Janssen ; Erz, D. ; Brecht, Marcus ; Collard, John G. ; Agatha C.M. Steenvoorden ; Bartram, Claus R. |
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Zeitschrift: | International Journal of Cancer, Jg. 113 (2004), S. 533-540 |
Veröffentlichung: | Wiley, 2004 |
Medientyp: | unknown |
ISSN: | 1097-0215 (print) ; 0020-7136 (print) |
DOI: | 10.1002/ijc.20626 |
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