Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients: RT-PCR swab positive and negative comparison
In: Journal of Infection and Public Health, Jg. 14 (2021), Heft 11, S. 1623-1629
Online
unknown
Zugriff:
Background COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative RT-PCR often presented with clinical manifestations of COVID-19. The data on such patients are lacking. The present study aims to characterize the patients who were suspected COVID-19 cases and tested negative in RT-PCR compared to patients who had been tested RT-PCR positive. Methods This is a retrospective, observational study of adult suspected and confirmed patients of COVID-19 admitted to King Saud University Medical City, Riyadh, Saudi Arabia, from 1st March 2020 until 30th November 2020. Laboratory confirmation is done through nasal/pharyngeal swab specimens, tested positive in RT-PCR assay. Patients with initial negative RT-PCR test results were assessed again within 48−72 h to avoid false-negative results. Patient data were extracted from the electronic medical files of each included patient using a predesigned case report form. Results The study included 488 (80.93%) patients with RT-PCR swab results positive, and 115 (19.07%) patients who were negative. Respiratory rate and diastolic blood pressure were higher among the swab-positive cases. More number of swab-negative patients had comorbidities such as coronary heart disease, chronic kidney disease, and carcinoma. Fever, cough, and shortness of breath were reported higher among the swab-positive cases. ALT and AST, and LDH levels were found higher among RT-PCR-positive patients. Serum creatinine, blood urea nitrogen and troponin were more elevated in RT-PCR-negative patients. Antibiotics, anticoagulants, and corticosteroids were used more by swab-positive patients. Significantly higher number of RT-PCR-positive patients required proning, high-flow nasal cannula, non-invasive mechanical ventilation, and invasive mechanical ventilation. Acute cardiac ischemia and death were found to be similar among the patients. However, deaths occurred significantly earlier among the swab-positive cases when compared to the swab-negative group. Conclusion Distinctive symptoms and markers of COVID-19 are more frequent among patients who had RT-PCR-positive results.
Titel: |
Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients: RT-PCR swab positive and negative comparison
|
---|---|
Autor/in / Beteiligte Person: | Dekhil, Hafedh ; Mohammed Faraj Alosaimi ; Siddiqui, Khalid ; Rafiullah, Mohamed ; Alotaibi, Naif ; Hasanato, Rana ; Altalhi, Haifa ; Alfadda, Assim A. ; Alayed, Khalid ; Almaghlouth, Ibrahim ; Albanyan, Saleh ; Isnani, Arthur C. ; Alzahrani, Musa ; Alarifi, Mohammed ; AlKhowaiter, Mohammad ; Youssef, Amira M. ; Binkhamis, Khalifa |
Link: | |
Zeitschrift: | Journal of Infection and Public Health, Jg. 14 (2021), Heft 11, S. 1623-1629 |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 1876-035X (print) |
Schlagwort: |
|
Sonstiges: |
|