Targeting the Mitochondria in Heart Failure
In: JACC: Basic to Translational Science JACC: Basic to Translational Science, Jg. 5 (2020), Heft 1, S. 88-106
Online
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Visual Abstract
Highlights • Cardiac energy deprivation due to mitochondrial dysfunction is characteristic of heart failure. • Mitochondrial dysfunction contributes to worsening of the heart failure state. • Pharmacologic targeting of mitochondria in heart failure is an unmet need. • Mitochondrial dysfunction in heart failure can be reversed with novel experimental drugs.
Summary The burden of heart failure (HF) in terms of health care expenditures, hospitalizations, and mortality is substantial and growing. The failing heart has been described as “energy-deprived” and mitochondrial dysfunction is a driving force associated with this energy supply-demand imbalance. Existing HF therapies provide symptomatic and longevity benefit by reducing cardiac workload through heart rate reduction and reduction of preload and afterload but do not address the underlying causes of abnormal myocardial energetic nor directly target mitochondrial abnormalities. Numerous studies in animal models of HF as well as myocardial tissue from explanted failed human hearts have shown that the failing heart manifests abnormalities of mitochondrial structure, dynamics, and function that lead to a marked increase in the formation of damaging reactive oxygen species and a marked reduction in on demand adenosine triphosphate synthesis. Correcting mitochondrial dysfunction therefore offers considerable potential as a new therapeutic approach to improve overall cardiac function, quality of life, and survival for patients with HF.
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Targeting the Mitochondria in Heart Failure
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Autor/in / Beteiligte Person: | Sabbah, Hani N. |
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Zeitschrift: | JACC: Basic to Translational Science JACC: Basic to Translational Science, Jg. 5 (2020), Heft 1, S. 88-106 |
Veröffentlichung: | Elsevier, 2020 |
Medientyp: | unknown |
ISSN: | 2452-302X (print) |
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