Common Surface‐AntigenvarGenes of Limited Diversity Expressed byPlasmodium falciparumPlacental Isolates Separated by Time and Space
In: The Journal of Infectious Diseases, Jg. 187 (2003-02-01), S. 477-483
Online
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Zugriff:
Plasmodium falciparum placental parasites from Cameroon have been shown to express surface variant var genes encoding Duffy binding-like (DBL)-gamma domains that bind chondroitin sulfate A. All 5 domains exhibited sequences with 39%-55% amino acid (aa) identities and appear sufficiently conserved to function in receptor binding. Transcripts of 2 samples showed complete conservation over 4 kb, demonstrating for the first time distinct conserved placental var genes. Four placental isolates from Gabon collected 4 years later expressed DBL-gamma sequences with 85%-99% aa identities to those from Cameroon, confirming the conserved nature of placental variants separated by time and location. Five peripheral parasites from children also displayed DBL-gamma sequences with 75%-97% homologies. From this, it can be concluded that P. falciparum parasites expressing unique var DBL-gamma genes can cause placental malaria, referred to as varPAM genes. This demonstration of structurally/functionally constrained DBL-gamma chondroitin sulfate A-binding domains is relevant to understanding pregnancy-associated malaria pathogenesis and to vaccine development.
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Common Surface‐AntigenvarGenes of Limited Diversity Expressed byPlasmodium falciparumPlacental Isolates Separated by Time and Space
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Autor/in / Beteiligte Person: | Klinkert, Mo-Quen ; Kremsner, Peter G. ; Khattab, Ayman |
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Zeitschrift: | The Journal of Infectious Diseases, Jg. 187 (2003-02-01), S. 477-483 |
Veröffentlichung: | Oxford University Press (OUP), 2003 |
Medientyp: | unknown |
ISSN: | 1537-6613 (print) ; 0022-1899 (print) |
DOI: | 10.1086/368266 |
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