Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy
In: Molecular Biology Reports, Jg. 48 (2021-01-23), S. 1687-1695
Online
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Zugriff:
Ischemia-reperfusion injury (IRI) is inevitable during liver surgery, and it is an important factor affecting the prognosis of patients. IL-6 rs1800796 single nucleotide polymorphisms (SNPs) can promote synthesis and secretion of IL-6 and protect hepatocytes from IRI. In this study, we investigated the mechanisms by which IL-6 alleviates hepatic IRI. We transfected lentivirus which carries IL-6 rs1800796 to L02 cells and constructed the cell line (L02-IL6) with a high expression of IL-6. The biological function of IL-6 SNPs was explored through a cell model of hypoxia-reoxygenation (H/R). Cell viability was evaluated by CCK8 and Real-Time Cell Analysis (RTCA), and found that the viability of the L02-IL6 cells was higher than that of the control group (P
| Titel: |
Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy
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| Autor/in / Beteiligte Person: | Gao, Jie ; Tang, Hongwei ; Hongbo, Fang ; Cao, Shengli ; Zhang, Shuijun ; Guo, Wenzhi ; Zhang, Huapeng ; Guo, Dan-Feng |
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| Zeitschrift: | Molecular Biology Reports, Jg. 48 (2021-01-23), S. 1687-1695 |
| Veröffentlichung: | Springer Science and Business Media LLC, 2021 |
| Medientyp: | unknown |
| ISSN: | 1573-4978 (print) ; 0301-4851 (print) |
| DOI: | 10.1007/s11033-020-06090-2 |
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