Serum 7α-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea
In: European Journal of Gastroenterology & Hepatology, Jg. 8 (1996-02-01), S. 117-124
Online
unknown
Zugriff:
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR).One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in two centres (Edinburgh and Sweden) by two different tests which measure bile acid loss or synthesis: the SeHCAT test which measures the 7-day SeHCAT WBR and serum 7 alpha-3ox-C which reflects the rate of bile acid synthesis.Forty-six patients had SeHCAT WBR of less than 10% (19 with ileal disease or resection, nine with idiopathic bile acid induced diarrhoea and 18 with miscellaneous causes for bile acid induced diarrhoea). All patients with ileal or idiopathic disease showed a favorable response to treatment as did 13 of the miscellaneous group. Serum 7 alpha-3ox-C was raised in all subjects with ileal disease/resection, seven patients with idiopathic disease and all subjects in the miscellaneous group who responded to treatment. Sixteen out of 118 patients with SeHCAT WBR greater than or equal to 10% had raised serum 7 alpha-3ox-C.The positive predictive value of serum 7 alpha-3ox-C was 74%. The high negative predictive value (98%) of serum 7 alpha-3ox-C indicates the possible use of this test for excluding bile acid malabsorption in this population. All but two subjects who responded to treatment had raised serum 7 alpha-3ox-C concentrations. The possibility that the sensitivity of the test can be improved by repeat testing needs to be further investigated. There was a significant correlation between fractional catabolic rate (FCR) SeHCAT and serum 7 alpha-3ox-C (r = 0.63, P0.0001). Further data are required to validate the reference range in women over 70 years of age.
Titel: |
Serum 7α-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea
|
---|---|
Autor/in / Beteiligte Person: | Brydon, W. G. ; Eastwood, M.A. ; Nyhlin, Henry ; Merrick, Malcolm V. |
Link: | |
Zeitschrift: | European Journal of Gastroenterology & Hepatology, Jg. 8 (1996-02-01), S. 117-124 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 1996 |
Medientyp: | unknown |
ISSN: | 0954-691X (print) |
DOI: | 10.1097/00042737-199602000-00005 |
Schlagwort: |
|
Sonstiges: |
|