NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines
In: The Journal of organic chemistry, Jg. 86 (2020-12-22), Heft 1
Online
unknown
Zugriff:
A general DBU-mediated one-pot three-component cycloaddition reaction of easily accessible malonic acid derivatives, nitrosoarenes, and alkenes has been successfully established with the aid of NBS to provide direct access to highly functionalized isoxazolidine derivatives with generally good to excellent yields, broad functional group tolerance, and excellent regio- and diastereo-selectivities under mild conditions. The mechanism study shows that the NBS-mediated formation of bromomalonic acid derivatives from malonic acid derivatives and DBU-promoted synthesis of nitrone intermediates
Titel: |
NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines
|
---|---|
Autor/in / Beteiligte Person: | Zheng, Leijie ; Gao, Wenchao ; Li, Xing ; Chang, Honghong ; Gong, Xiaolei ; Wei, Wenlong |
Link: | |
Zeitschrift: | The Journal of organic chemistry, Jg. 86 (2020-12-22), Heft 1 |
Veröffentlichung: | 2020 |
Medientyp: | unknown |
ISSN: | 1520-6904 (print) |
Schlagwort: |
|
Sonstiges: |
|